Synthesis of fluorescent artificial receptors with high specificity for simultaneous detection of non-steroidal anti-inflammatory drugs

文献类型： 外文期刊

第一作者： Wang, Tingting

作者： Wang, Tingting;Li, Qianjin;Wang, Meng;Li, Jianlin;Wang, Fenying;Xu, Jianhong

作者机构：

关键词： Molecularly imprinted polymer; Fluorescence; Naproxen; Ketoprofen; Sensor

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2023 年 410 卷

页码：

收录情况： SCI

摘要： Development of multiple detection methods to monitor non-steroidal anti-inflammatory drugs (NSAIDs) in food is an effective way to protect human health. Here, we aimed to synthesize fluorescent artificial receptors by molecular imprinting technique to construct a simultaneous detection system targeting NSAIDs. Rhodamine B and fluorescein-functionalized silanes were employed as the fluorescence signal reporters for naproxen and ketoprofen, respectively. Two fluorescent molecularly imprinted polymers (FMIPs) were obtained with high specificity, giving cross-reactivity factors of 6.4-15.8 (naproxen) and 2.6-25.6 (ketoprofen). Both FMIPs also displayed rapid response time (5 min) and high sensitivity (detection limit at similar to nM level). A simultaneous detection system was constructed based on the FMIPs and applied for sensing the spiked NSAIDs in real samples, showing recoveries of 71-119 %, comparable with the HPLC methods (70-113 %). In summary, use of different FMIPs to construct simultaneous detection systems is practicable, and provides a flexible way for sensing multiple hazards in food samples.

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