Therapeutic Effect and Safety Evaluation of Naringin on Klebsiella pneumoniae in Mice

文献类型： 外文期刊

第一作者： Zhao, Guanyu

作者： Zhao, Guanyu;Huang, Qilin;Jing, Xiaohan;Liu, Chen;Pan, Xiangyi;Li, Zhaorong;Li, Sifan;Qiu, Zhengying;Xin, Ruihua;Zhao, Guanyu;Huang, Qilin;Jing, Xiaohan;Liu, Chen;Pan, Xiangyi;Li, Zhaorong;Li, Sifan;Qiu, Zhengying;Xin, Ruihua;Zhao, Guanyu;Huang, Qilin;Jing, Xiaohan;Liu, Chen;Pan, Xiangyi;Li, Zhaorong;Li, Sifan;Qiu, Zhengying;Xin, Ruihua;Huang, Lina

作者机构：

关键词： flavonoids; naringin (NAR); Klebsiella pneumoniae (Kpn); bacterial pneumonia; anti-inflammatory; drug safety

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

ISSN： 1661-6596

年卷期： 2023 年 24 卷 21 期

页码：

收录情况： SCI

摘要： Critically ill patients with Corona Virus Disease 2019 (COVID-19) often develop secondary bacterial infections that pose a significant threat to patient life safety, making the development of drugs to prevent bacterial infections in the lungs critical to clinical care. Naringin (NAR) is one of the significant natural flavonoids rich in Pummelo Peel (Hua Ju Hong), with anti-inflammatory, antimicrobial, and antioxidant activities, and is commonly used in treating respiratory tract infectious diseases. In this study, the in vitro and in vivo findings revealed that, after Klebsiella pneumoniae (Kpn) infection, NAR inhibited overactivation of the nuclear factor kappa-B(NF-kappa B) signaling pathway in alveolar macrophages of mice, reduced neutrophil (NEs) recruitment, and lowered the induced production of proinflammatory markers, such as Interleukin-6(IL-6) and tumor necrosis factor alpha(TNF-alpha). Thus, it suppressed excessive immune responses in the lungs, as well as attenuated the induced pulmonary fibrosis and inflammatory infiltrates. These results suggest that NAR has a preventive effect against Kpn in mice. In addition, the study evaluated NAR's potential toxicity, demonstrating that NAR is safe at effective doses. These results suggested that NAR effectively reduces excessive inflammatory damage in the lungs induced by Kpn and enhances the body's ability to clear bacteria. Therefore, NAR may be an effective and safe healthcare drug for preventing and caring for bacterial pneumonia.

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