Whole-genome resequencing to unveil genetic characteristics and selection signatures of specific pathogen-free ducks

文献类型： 外文期刊

第一作者： Li, Lanlan

作者： Li, Lanlan;Gao, Caixia;Liu, Hongyi;Yu, Haibo;Chen, Hongyan;Xia, Changyou;Li, Lanlan;Quan, Jinqiang;Zhao, Shengguo

作者机构：

关键词： laboratory ducks; whole-genome resequencing; genetic characteristics; selection signature; single nucleo-tide polymorphisms

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 7 期

页码：

收录情况： SCI

摘要： Specific pathogen-free ducks are impor-tant high-grade laboratory animals, with a key role in research related to poultry biosecurity, production, and breeding. However, the genetic characteristics of experi-mental duck varieties remain poorly explored. Herein we performed whole-genome resequencing to construct a single nucleotide polymorphism genetic map of the genomes of 3 experimental duck varieties [Jinding ducks (JD), Shaoxing ducks (SX), and Fujian Shanma ducks (SM)] to determine their genetic characteristics and identify selection signatures. Subsequent analyses of population structure and genetic diversity revealed that each duck variety formed a monophyletic group, with SM showing richer genetic diversity than JD and SX. Further, on exploring shared selection signatures, we found 2 overlapping genomic regions on chromosome Z of all experimental ducks, which comprised immune response-related genes (IL7R and IL6ST). Moreover, growth and skeletal development (IGF1R and GDF5), meat quality (FoxO1), and stress resistance (HSP90B1 and Gpx8-b) candidate gene loci were identified in strongly selected signatures specific to JD, SM, and SX, respectively. Our results identified the population genetic basis of experimental ducks at the whole-genome level, providing a framework for future molecular inves-tigations of genetic variations and phenotypic changes. We believe that such studies will eventually contribute to the management of experimental animal resources.

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