Combined Omics Analysis Further Unveils the Specific Role of Butyrate in Promoting Growth in Early-Weaning Animals
文献类型: 外文期刊
第一作者: Zhang, Bin
作者: Zhang, Bin;Liu, Mengqi;Yue, Zhengkai;Chen, Xiaoyang;Li, Chenyang;Liu, Lei;Li, Fuchang;Chen, Xiaoyang;Li, Chenyang;Chen, Xiaoyang;Li, Chenyang
作者机构:
关键词: dietary butyrate; early weaning; intestinal epithelial barrier; microbiome-metabolome; inflammation and appetite; microbe-gut-brain axis
期刊名称:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ( 影响因子:5.6; 五年影响因子:6.2 )
ISSN:
年卷期: 2023 年 24 卷 2 期
页码:
收录情况: SCI
摘要: Abnormal mutations in the microbial structure of early-weaning mammals are an important cause of enteritis. Based on the multiple known beneficial functions of butyrate, we hypothesized that butyrate would alleviate the imbalance of intestinal homeostasis induced by early weaning in animals. However, the mechanisms of action between butyrate and intestinal microbes are still poorly explored. In this study, we aimed to investigate whether butyrate exerts beneficial effects on the structure of the intestinal flora of weanling rabbits and their intestinal homeostasis, growth and development, and we attempted to elucidate the potential mechanisms of action through a combined omics analysis. We found that dietary butyrate upregulated the transcription of tight junction-related proteins in the epithelial barrier and improved the intestinal microbial structure by suppressing harmful bacteria and promoting beneficial ones. Intestinal and plasma metabolomes were also altered. The bile acid secretion, alpha-linolenic acid, apoptotic, and prostate cancer pathways responded to the positive dietary butyrate-induced metabolic changes in the weanling rabbits, resulting in the inhibition of inflammation, improved antioxidant capacity, increased rates of cell proliferation and survival, and decreased levels of apoptosis. Additionally, dietary butyrate suppressed the release of pro-inflammatory factors and enhanced positive appetite regulation, which increased the average daily gain of the rabbits. These results demonstrated that dietary butyrate can help maintain the integrity of the intestinal epithelial barrier, improve the structural composition of the intestinal microflora, enhance organismal metabolism, inhibit inflammation, reduce post-weaning anorexia, and promote growth and development in early-weaning rabbits. These positive effects of dietary butyrate were exerted via the modulation of the microbe-gut-brain axis.
分类号:
- 相关文献
作者其他论文 更多>>
-
Identification of mould varieties infecting maize kernels based on Raman hyperspectral imaging technique combined with multi-channel residual module convolutional neural network
作者:Long, Yuan;Tang, Xiuying;Zhang, Bin;Long, Yuan;Fan, Shuxiang;Zhang, Chi;Huang, Wenqian;Long, Yuan;Fan, Shuxiang;Zhang, Chi;Huang, Wenqian
关键词:Raman hyperspectral imaging; Maize kernels; Mould varieties; Residual unit; Nondestructive detection
-
Initial soil moisture prewinter affects the freeze-thaw profile dynamics of a Mollisol in Northeast China
作者:Wen, Yanru;Liu, Bao;Wu, Wenbin;Liu, Bao;Li, Ting-Yong;Jiang, Heng;Zhang, Bin
关键词:Soil moisture prewinter; Soil water storage; Freeze-thaw process; Soil profile; Mollisol
-
Liming reduces nitrogen uptake from chemical fertilizer but increases that from straw in a double rice cropping system
作者:Liao, Ping;Liao, Ping;van Groenigen, Kees Jan;Liu, Lei;Sun, Yanni;Huang, Shan;Zeng, Yongjun;Chen, Jin;Chen, Jin
关键词:Yield; N recovery rate; N losses; Soil acidification; 15 N tracing
-
Interaction of lime application and straw retention on ammonia emissions from a double-cropped rice field
作者:Liao, Ping;Zhang, Hongcheng;Liu, Lei;Liu, Jinsong;Sun, Yanni;Zeng, Yongjun;Huang, Shan;Liu, Lei;Bell, Stephen M.
关键词:NH3 emission; Liming; Straw retention; N losses; Soil acidification
-
Bacterial Community Characteristics Shaped by Artificial Environmental PM2.5 Control in Intensive Broiler Houses
作者:Wang, Wenxing;Dang, Guoqi;Khan, Imran;Liu, Lei;Zhong, Ruqing;Chen, Liang;Ma, Teng;Zhang, Hongfu;Ye, Xiaobin
关键词:airborne bacteria; PM2; 5; environmental control variables; manurial bacteria; broiler rearing
-
Quantification of Physiological Parameters of Rice Varieties Based on Multi-Spectral Remote Sensing and Machine Learning Models
作者:Liu, Shiyuan;Chen, Tingting;Zhang, Hui;Tan, Jiangtao;Li, Xi;Gao, Yu;Yao, Suzhe;Zhang, Lei;Zhang, Bin;Yang, Weiguang;Lin, Yongda;Lan, Yubin
关键词:rice; physiological parameters; UAV; machine learning
-
Responses of grassland productivity to mowing intensity and precipitation variability in a temperate steppe
作者:Zhang, Feng;Zhang, Bin;Zhao, Tianqi;Zhao, Mengli;Han, Guodong;Bennett, Jonathan A.;Zhao, Tianqi;Zhao, Tianqi;Bai, Keyu;Bai, Keyu
关键词:Mowing; Precipitation; Graminoids; Forbs; Legacies