Systematic assessment of cyflumetofen toxicity in soil-earthworm (Eisenia fetida) microcosms
文献类型: 外文期刊
第一作者: Shi, Linlin
作者: Shi, Linlin;Xu, Jun;Wu, Xiaohu;Pan, Xinglu;Dong, Fengshou;Zhang, Ping;He, Lin;Zheng, Yongquan
作者机构:
关键词: Cyflumetofen; Oxidative stress; Transcriptome sequencing; Integrated Biological Responses version 2; Detoxification mechanism
期刊名称:JOURNAL OF HAZARDOUS MATERIALS ( 影响因子:13.6; 五年影响因子:12.7 )
ISSN: 0304-3894
年卷期: 2023 年 452 卷
页码:
收录情况: SCI
摘要: Cyflumetofen was widely applied in agriculture with its excellent acaricidal effect. However, the impact of cyflumetofen on the soil non-target organism earthworm (Eisenia fetida) is unclear. This study aimed to elucidate the bioaccumulation of cyflumetofen in soil-earthworm systems and the ecotoxicity of earthworms. The highest concentration of cyflumetofen enriched by earthworms was found on the 7th day. Long-term exposure of earthworms to the cyflumetofen (10 mg/kg) could suppress protein content and increases Malondialdehyde content leading to severe peroxidation. Transcriptome sequencing analysis demonstrated that catalase and superoxide-dismutase activities were significantly activated while genes involved in related signaling pathways were significantly upregulated. In terms of detoxification metabolic pathways, high concentrations of cyflumetofen stimulated the number of Differentially-Expressed-Genes involved in the detoxification pathway of the metabolism of glutathione. Identification of three detoxification genes (LOC100376457, LOC114329378, and JGIBGZA-33J12) had synergistic detoxification. Additionally, cyflumetofen promoted disease-related signaling pathways leading to higher disease risk, affecting the transmembrane capacity and cell membrane composition, ultimately causing cytotoxicity. Superoxide-Dismutase in oxidative stress enzyme activity contributed more todetoxification. Carboxylesterase and glutathione-S-transferase activation play a major detoxification role in high -concentration treatment. Altogether, these results contribute to a better understanding of toxicity and defense mechanisms involved in long-term cyflumetofen exposure in earthworms.
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