Emergence of a novel pathogenic recombinant virus from Bartha vaccine and variant pseudorabies virus in China
文献类型: 外文期刊
第一作者: Bo, Zongyi
作者: Bo, Zongyi;Miao, Yurun;Xi, Rui;Gao, Xiaoyu;Chen, Huan;Jung, Yong-Sam;Qian, Yingjuan;Dai, Jianjun;Gao, Xiaoyu
作者机构:
关键词: complete genome sequence; natural recombination; pathogenicity; phylogenetic analysis; pseudorabies virus
期刊名称:TRANSBOUNDARY AND EMERGING DISEASES ( 影响因子:5.005; 五年影响因子:4.622 )
ISSN: 1865-1674
年卷期:
页码:
收录情况: SCI
摘要: Pseudorabies virus (PRV), the causative agent of Aujeszky's disease, has resulted in substantial economic losses in the swine industry worldwide. Previous reports have shown that the PRV variant is responsible for the Pseudorabies outbreaks in Bartha-K61-vaccinated farms in China. However, there is limited information about the evolution of recombination of the PRV variant. Here, we isolated two PRV variants from a Bartha-K61-vaccinated swine farm, named them the JSY7 and JYS13 strains, analysed their complete genomic sequences and evaluated pathogenicity. As results, the JSY7 and JSY13 strains showed different cytopathic effects and plaque sizes. The JSY7 and JSY13 strains had the same Aspartate insertions in the gE protein as other PRV variants. The JSY7 and JSY13 strains were clustered into the same clade based on a genomic phylogenetic analysis. However, the JSY7 strain was relatively close to recent PRV isolates in China, while the JSY13 strain was more closely related to earlier PRV isolates. Interestingly, the gC gene phylogenetic tree showed that the JSY7 strain belonged to genotype II lineage 3, while the JSY13 strain belonged to genotype I and is the same branch with the Bartha strain. Furthermore, the PRV variants were relatively distant from the Bartha strain in the phylogenetic analysis of the gB, gC and gD genes. Importantly, a recombination analysis showed that the JSY13 strain might be a natural recombinant between the minor parental genotype I Bartha strain and the major parental genotype II JSY7 strain. Finally, we also found that the JSY13 strain showed a moderate virulence compared to the JSY7 strain in mice. Taken together, our data provide direct evidence for genomic recombination of PRV in nature, which may play an important role in the evolution and virulence of PRV. This discovery suggests that live PRV vaccine can act as genetic donors for genomic recombination.
分类号:
- 相关文献
作者其他论文 更多>>
-
Interaction of a bacterial non-classically secreted RNase HI with a citrus B-Box zinc finger protein delays flowering in Arabidopsis thaliana and suppresses the expression of FLOWERING LOCUS T
作者:Du, Peixiu;Li, Weimin;Du, Peixiu;Du, Peixiu;Li, Weimin;Hu, Junxia;Gao, Xiaoyu;Yang, Wendi;Li, Weimin;Du, Meixia;Zou, Xiuping;Wang, Xuefeng;Zhang, Chao
关键词:Candidatus Liberibacter asiaticus; Non-classically secreted protein; RNase HI; B-box zinc finger protein; Flowering; FLOWERING LOCUS T
-
Calcineurin B-like interacting protein kinase 31 confers resistance to sheath blight via modulation of ROS homeostasis in rice
作者:Chen, Huan;Lin, Qiujun;Li, Zhuo;Mei, Qiong;Xuan, Yuanhu;Lin, Qiujun;Chu, Jin;Dong, Hai;Mei, Qiong;Xuan, Yuanhu
关键词:CIPK31; homeostasis; resistance; rice; ROS; sheath blight
-
Stable isotope characterization of tobacco products: A determination of synthetic or natural nicotine authenticity
作者:Han, Shulei;Cui, Lili;Chen, Huan;Fu, Ya'ning;Hou, Hongwei;Hu, Qingyuan;Han, Shulei;Cui, Lili;Chen, Huan;Fu, Ya'ning;Hou, Hongwei;Hu, Qingyuan;Yuan, Yuwei;Hou, Hongwei;Hu, Qingyuan
关键词:
-
The transcriptional regulatory network of hormones and genes under salt stress in tomato plants (Solanum lycopersicum L.)
作者:Wang, Baike;Wang, Juan;Yang, Tao;Dai, Qi;Zhang, Fulin;Xi, Rui;Yu, Qinghui;Li, Ning;Wang, Jinxin;Zhang, Fulin;Xi, Rui
关键词:tomato; salt stress; hormone; RNA-seq; WGCNA
-
MicroRNA408 negatively regulates salt tolerance by affecting secondary cell wall development in maize
作者:Qin, Ruidong;Hu, Yumei;Chen, Huan;Du, Qingguo;Yang, Juan;Li, Wen-Xue
关键词:
-
HDAC6 Triggers the ATM-Dependent DNA Damage Response To Promote PRV Replication
作者:Xu, Weiyin;Yan, Ping;Zhou, Ziyan;Yao, Jingting;Pan, Haochun;Jiang, Luyao;Bo, Zongyi;Gao, Song;Huan, Changchao;Xu, Weiyin;Yan, Ping;Zhou, Ziyan;Yao, Jingting;Pan, Haochun;Jiang, Luyao;Gao, Song;Huan, Changchao;Xu, Weiyin;Yan, Ping;Zhou, Ziyan;Yao, Jingting;Pan, Haochun;Jiang, Luyao;Gao, Song;Huan, Changchao;Xu, Weiyin;Yan, Ping;Zhou, Ziyan;Yao, Jingting;Pan, Haochun;Jiang, Luyao;Gao, Song;Huan, Changchao;Ni, Bo;Sun, Mingxia
关键词:PRV; HDAC6; DNA damage; p-H2AX; ATM
-
Characterization and phylogenetic analysis of bovine gammaherpesvirus 4 isolated in China, 2022
作者:Guo, Weiqiang;Sun, Tong;Liu, Yingnan;Duan, Xulai;Tian, Chuanwen;Zhou, Zhou;Liu, Jingyi;Chen, Hongjun;Guo, Weiqiang;Liu, Yingnan;Duan, Xulai;Tian, Chuanwen;Zhou, Zhou;Guo, Weiqiang;Jung, Yong-Sam
关键词:Bovine gammaherpesvirus 4 (BoHV-4); Isolation; Phylogenetic analysis