Fluorogenic recognition of Zn2+, Cd2+ by a new Pyrazoline-based Multi-Analyte chemosensor and its application in live cell imaging

文献类型： 外文期刊

第一作者： Zhang, Ying-Peng

作者： Zhang, Ying-Peng;Niu, Wei -Ya;Ma, Chun-Mei;Yang, Yun-Shang;Guo, Hui-Chen;Guo, Hui-Chen;Xue, Ji -Jun;Xue, Ji -Jun

作者机构：

关键词： Pyrazoline; Zinc; Cadmium; Fluorescent chemosensor; Biological application

期刊名称：INORGANIC CHEMISTRY COMMUNICATIONS （ 影响因子：2.495； 五年影响因子：1.887 ）

ISSN： 1387-7003

年卷期： 2021 年 130 卷

页码：

收录情况： SCI

摘要： A novel multi-response pyrazoline-based fluorescent probe 1 was designed and synthesized with a very simple molecular structure, which exhibited high sensitivity for detecting Zn2+ and Cd2+ in ethanol aqueous solution state based on the dissuasion of intramolecular charge transfer (ICT) and chelation-enhanced fluorescence (CHEF) effect. The binding modes of the complexes were determined to have 1:1 complexation stoichiometry and the binding constants were calculated to be 1.284 x 104 M-1 for Zn2+ and 4.313 x 103 M-1 for Cd2+ using the nonlinear curve-fitting method. Zn2+ and Cd2+ sensor have high anti-interference ability. Under optimal conditions, the detection limits were determined to be 0.9274 mu M for Zn2+ and 0.8158 mu M for Cd2+. Notably, the probe was found to have good biological compatibility and was employed to detect Zn2+/ Cd2+ in living Hela cells.

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