High-fat diet-disturbed gut microbiota-colonocyte interactions contribute to dysregulating peripheral tryptophan-kynurenine metabolism
文献类型: 外文期刊
第一作者: Sun, Penghao
作者: Sun, Penghao;Wang, Mengli;Chen, Shulin;Zhu, Xiaoyan;Zhao, Shanting;Liu, Yong-Xin;Li, Luqi;Chai, Xuejun;Zheng, Wei
作者机构:
关键词: High-fat diet; Gut microbiota; Tryptophan metabolism; Kynurenine; Mitochondrial dysfunction
期刊名称:MICROBIOME ( 影响因子:15.5; 五年影响因子:19.4 )
ISSN: 2049-2618
年卷期: 2023 年 11 卷 1 期
页码:
收录情况: SCI
摘要: Background Aberrant tryptophan (Trp)-kynurenine (Kyn) metabolism has been implicated in the pathogenesis of human disease. In particular, populations with long-term western-style diets are characterized by an excess of Kyn in the plasma. Host-gut microbiota interactions are dominated by diet and are essential for maintaining host metabolic homeostasis. However, the role of western diet-disturbed gut microbiota-colonocyte interactions in Trp metabolism remains to be elucidated. Results Here, 4-week-old mice were fed with a high-fat diet (HFD), representing a typical western diet, for 4 weeks, and multi-omics approaches were adopted to determine the mechanism by which HFD disrupted gut microbiota-colonocyte interplay causing serum Trp-Kyn metabolism dysfunction. Our results showed that colonocyte-microbiota interactions dominated the peripheral Kyn pathway in HFD mice. Mechanistically, persistent HFD-impaired mitochondrial bioenergetics increased colonic epithelial oxygenation and caused metabolic reprogramming in colonites to support the expansion of Proteobacteria in the colon lumen. Phylum Proteobacteria-derived lipopolysaccharide (LPS) stimulated colonic immune responses to upregulate the indoleamine 2,3-dioxygenase 1 (IDO1)-mediated Kyn pathway, leading to Trp depletion and Kyn accumulation in the circulation, which was further confirmed by transplantation of Escherichia coli (E.coli) indicator strains and colonic IDO1 depletion. Butyrate supplementation promoted mitochondrial functions in colonocytes to remodel the gut microbiota in HFD mice, consequently ameliorating serum Kyn accumulation. Conclusions Our results highlighted that HFD disrupted the peripheral Kyn pathway in a gut microbiota-dependent manner and that the continuous homeostasis of gut bacteria-colonocytes interplay played a central role in the regulation of host peripheral Trp metabolism. Meanwhile, this study provided new insights into therapies against western diet-related metabolic disorders.
分类号:
- 相关文献
作者其他论文 更多>>
-
Effects of pH-shifting treatments on the emulsifying properties of rice protein isolates: Quantitative analysis of interfacial protein layer
作者:Shen, Qian;Dai, Hongmin;Wen, Luming;Zheng, Wei;Li, Beixi;Li, Bin;Chen, Yijie;Dai, Jun;Chen, Yijie;Chen, Yijie
关键词:Rice protein isolate (RPI); pH-shifting treatment; Interfacial adsorption; Quantitative proteomics; Emulsion; Interfacial rheology
-
Comparative Proteomic Analysis of Milk-Derived Extracellular Vesicles from Dairy Cows with Clinical and Subclinical Mastitis
作者:Wang, Mengling;Cai, Meng;Zhu, Xiaoyan;Nan, Xuemei;Xiong, Benhai;Yang, Liang
关键词:milk; extracellular vesicles; proteome; cow; mastitis
-
Effect of bio-nano-selenium on yield, nutritional quality and selenium content of radish
作者:Huang, Sisi;Yu, Kan;Song, Banghui;Long, Xiaoling;Cai, Duanwu;Zheng, Wei;Xiao, Qiushui;Yuan, Weiling;Xiong, Xuxing
关键词:Bio-nano-selenium; Food analysis; Food composition; Yield; Radish
-
Characterization and evolutionary analysis of phosphate starvation response genes in wheat and other major gramineous plants
作者:Sun, Renwei;Gong, Jie;Zhang, Shengquan;Ma, Jinxiu;Zhang, Fengting;Liu, Yongjie;Liao, Xiangzheng;Sun, Hui;Pang, Binshuang;Zhao, Changping;Gao, Shiqing;Sun, Renwei;Gong, Jie;Du, Yinke;Ma, Jinxiu;Liu, Yongjie;Pang, Binshuang;Zhao, Changping;Gao, Shiqing;Du, Yinke;Zheng, Wei;Sun, Renwei
关键词:Phosphate starvation; Phylogeny; Protein-protein interaction
-
Nonlinear rheological behavior and quantitative proteomic analysis of pea protein isolates at the air-water interface
作者:Shen, Qian;Luo, Yilun;Zheng, Wei;Xiong, Ting;Han, Fei;Zuo, Jingnan;Li, Bin;Chen, Yijie;Dai, Jun;Chen, Yijie;Chen, Yijie
关键词:Pea protein; Foam; Interface rheology; Lissajous plot; Quantitative analysis
-
Quantitative analysis and interfacial properties of mixed pea protein isolate-phospholipid adsorption layer
作者:Shen, Qian;Zheng, Wei;Han, Fei;Song, Rong;Li, Jing;Li, Yan;Li, Bin;Chen, Yijie;Dai, Jun;Chen, Yijie;Chen, Yijie
关键词:Pea protein isolate; Sequential adsorption; Quantitative proteomics
-
Metabolomics and Proteomics Responses of Largemouth Bass (Micropterus salmoides) Muscle under Organic Selenium Temporary Rearing
作者:Li, Hailan;Liu, Wenbo;Liao, Tao;Qiu, Jianhui;Xiong, Guangquan;Zu, Xiaoyan;Liu, Wenbo;Zheng, Wei
关键词:organic selenium; Micropterus salmoides muscle; temporary rearing; metabolomics; proteomics