Si-rhodamine fluorescent probe for monitoring of hypochlorous acid in the brains of mice afflicted with neuroinflammation

文献类型： 外文期刊

第一作者： Liang, Fanghui

作者： Liang, Fanghui;Jiang, Jian;Zhang, Guoyang;Zhou, Jiaying;Han, Jiahao;Geng, Yujie;Wang, Zhuo;Yang, Xinyue

作者机构：

期刊名称：CHEMICAL COMMUNICATIONS （ 影响因子：4.9； 五年影响因子：4.9 ）

ISSN： 1359-7345

年卷期： 2023 年 59 卷 10 期

页码：

收录情况： SCI

摘要： Neuroinflammation leads to a persistent oxidative stress in the brain, and is closely related to the pathology of various neurological disorders. Hypochlorous acid (HClO) is a reactive oxygen species (ROS) that, at high levels, can cause brain tissue damage and neurogenic apoptosis. Herein, we designed and synthesized a silicon-rhodamine (SiR)-based formohydrazide (FH)-containing fluorescent probe, denoted as SiR-FH, for sensing HClO. This probe showed good selectivity, rapid response and high sensitivity. SiR-FH was successfully used to detect endogenous and exogenous HClO in living cells. Moreover, SiR-FH realized real-time monitoring of change in HClO flux in the brains of mice with LPS-induced neuroinflammation. The probe provides a practical tool for the monitoring of oxidative stress related to neuroinflammation.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序