Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus

文献类型： 外文期刊

第一作者： Jin Li

作者： Jin Li;Wang HongYan;Wang XiaoNing;Yang Zhong;Zhong Yang;Zhao GuoPing;Wu Di;Xu TianLei;Sun Jing;Cao ZhiWei;Wu Di;Yang Zhong;Zhong Yang;Li YiXue;Cao ZhiWei;Dai JianXin;Wang Hao;Guo YaJun;Wang XiaoNing;Dai JianXin;Wang Hao;Guo YaJun;Che XiaoYan;Huang Zhong;Lan Ke;Sun Bing;Wu Fan;Yuan ZhenAn;Zhang Xi;Ding GuoHui;He YunGang;Bian Chao;Jin Li;Zhao GuoPing;Li YiXue;Ding GuoHui;He YunGang;Bian Chao;Jin Li;Zhao GuoPing;Li YiXue;Ding GuoHui;He YunGang;Bian Chao;Jin Li;Zhao GuoPing;Li YiXue;Ding GuoHui;He YunGang;Bian Chao;Jin Li;Zhao GuoPing;Li YiXue;Ding GuoHui;He YunGang;Bian Chao;Jin Li;Zhao GuoPing;Li YiXue;Zhou ZhengFeng;Xiong Hui;Dong Hui;Jin WeiRong;Jin Li;Zhao GuoPing;Zhou XiaoNong;Zhou JiaHai;Ma ZhiYong;Tong GuangZhi;Zhao GuoPing

作者机构：

关键词： novel H1N1 influenza virus;HA protein;spatial epitope;bioinformatics

期刊名称：CHINESE SCIENCE BULLETIN （ 影响因子：1.649； 五年影响因子：1.738 ）

ISSN： 1001-6538

年卷期： 2009 年 54 卷 13 期

页码：

收录情况： SCI

摘要： In recent months, a novel influenza virus H1N1 broke out around the world. With bioinformatics technology, the 3D structure of HA protein was obtained, and the epitope residues were predicted with the method developed in our group for this novel flu virus. 58 amino acids were identified as potential epitope residues, the majority of which clustered at the surface of the globular head of HA protein. Although it is located at the similar position, the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses.

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