a b
文献类型: 外文期刊
第一作者: Zheng, Meiyu
作者: Zheng, Meiyu;Wang, Lu;Zhang, Wenjuan;Gao, Pu;Lu, Shengmin;Sun, Yuqing;Pi, Xionge;Liu, Wei
作者机构:
关键词: Phellinus baumii; STZ-induced; Hypoglycemic effect; In vitro fermentation; Intestinal flora
期刊名称:BIOMEDICINE & PHARMACOTHERAPY ( 影响因子:7.5; 五年影响因子:6.8 )
ISSN: 0753-3322
年卷期: 2023 年 158 卷
页码:
收录情况: SCI
摘要: Phellinus baumii extract (PBE) possesses considerable alpha-glucosidase-inhibited activity. This study investigated the hypoglycemic effect in vitro and in vivo using a glucose consumption assay in HepG2 cells, intragastric admin-istration for ten weeks in STZ-induced mice, and intestinal flora fermentation in patients with type 2 diabetes to reveal the possible underlying mechanisms. PBE was prepared, including alpha-glucosidase-inhibited ethanol extract (EE) and aqueous extract (AE). In vitro, PBE promoted glucose consumption and enhanced glycogen content and hexokinase activity but lowered phosphoenolpyruvate carboxylase kinase activity in HepG2 cells. In vivo, PBE treatment significantly reduced the body weight (p < 0.05) and fasting blood glucose levels of diabetic mice (p < 0.01), with the lowest blood glucose level observed in the EE+AE group. Furthermore, the serum insulin levels and insulin resistance index (HOMA) of PBE-treated groups decreased significantly (p < 0.01). Moreover, gene expression levels of the IRS-1/PI3K/AKT pathway were significantly upregulated by PBE treatment (p < 0.01). In vitro fermentation demonstrated that EE significantly inhibited the production of H2S and NH3 in the intestinal flora fermentation model in diabetic patients (p < 0.05). In addition, the ratio of Firmicutes to Bacteroidetes was reduced, the growth of Lactobacillus and Prevotella 9 was promoted, and Pseudomonas aeruginosa was inhibited. This study provides new insights and clues for using PBE as a functional food and clinical drug for glycemic control.
分类号:
- 相关文献
作者其他论文 更多>>
-
Flavor characteristics of Shanlan rice wines fermented for different time based on HS-SPME-GC-MS-O, HS-GC-IMS, and electronic sensory analyses
作者:Hao, Yaofei;Zhao, Zhiheng;Xu, Wen;Wang, Lu;Lin, Xue;Hu, Xiaoping;Li, Congfa;Li, Jianxun
关键词:Shanlan rice wines; Fermentation time; Flavor characteristic; GC-MS-O; GC-IMS; Electronic sensory
-
Bacterial, short-chain fatty acid and gas profiles of partially hydrolyzed guar gum in vitro fermentation by human fecal microbiota
作者:Pi, Xiong-E;Fu, Hao;Quan, Hui Hui;Lu, Li-Zhi;Liu, Wei;Yang, Xiao-Xia;Yu, Zai-Chun;Zhang, Yinjun;Teng, Wei-Lin;Ye, Xue-Wei
关键词:Partially hydrolyzed guar gum; Gas production; SCFAs; Gut microbiota
-
Methylglyoxal scavenging capacity of fiber-bound polyphenols from highland barley during colonic fermentation and its modulation on methylglyoxal-interfered gut microbiota
作者:Li, Jinxin;Zhu, Ling;Wu, Gangcheng;Zhang, Hui;Zhang, Hao;Liu, Wei;Yang, Xijuan;Zhang, Hui
关键词:Bound phenolic compounds; Methylglyoxal; Gut microbiota; Colonic fermentation; Scavenging capacity
-
Insights into key aroma of vine tea (Ampelopsis grossedentata) for grade evaluation integrating relative odor activity value, gas chromatography-olfactometry and chemometrics approaches
作者:Li, Qianqian;Zhou, Xiaoqian;Li, Yi;Li, Jianxun;Li, Bei;Xie, Zuorong;Zhang, Chaoyang;Liu, Wei;Mi, Yu
关键词:Vine tea; rOAV; GC-O; Grade; Chemometrics methods
-
Morganella morganii, a bacterial pathogen in diseased Chinese soft-shelled turtles (Pelodiscus sinensis)
作者:Zhai, Jiale;Xiao, Zidong;Xue, Mingyang;Fan, Yuding;Meng, Yan;Liu, Wei;Hu, Xiaowei;Xing, Yangyang;Jiang, Nan;Zhou, Yong;Zhai, Jiale
关键词:Pelodiscus sinensis; Morganella morganii; Pathological features; Intestinal microorganisms
-
Effect of Lactobacillus salivarius SNK-6 on egg quality, intestinal morphology, and cecal microbial community of laying hens
作者:Liu, Wei;Liu, Jie;Li, Dapeng;Han, Haixia;Sun, Yan;Lei, Qiuxia;Wang, Jie;Zhou, Yan;Cao, Dingguo;Li, Huimin;Li, Fuwei;Liu, Wei;Liu, Jie;Li, Dapeng;Han, Haixia;Sun, Yan;Lei, Qiuxia;Wang, Jie;Zhou, Yan;Cao, Dingguo;Li, Huimin;Li, Fuwei;Liu, Wei;Liu, Jie;Li, Dapeng;Han, Haixia;Sun, Yan;Lei, Qiuxia;Wang, Jie;Zhou, Yan;Cao, Dingguo;Li, Huimin;Li, Fuwei;Yan, Huaxiang
关键词:Lactobacillus salivarius; egg quality; intestinal morphology; cecal microbial community; laying hen
-
A CRISPR-Cas12a-based platform facilitates the detection and serotyping of Streptococcus suis serotype 2
作者:Wang, Lu;Sun, Jing;Zhao, Jiyu;Bai, Jieyu;Zhang, Yueling;Zhu, Yao;Zhang, Wanjiang;Wang, Chunlai;Liu, Siguo;Li, Gang;Wang, Lu;Bai, Jieyu;Zhao, Jiyu;Langford, Paul R.
关键词:CRISPR; Cas12a; crRNA; Streptococcus suis serotype 2; Diagnostics