Goose haemorrhagic hepatitis caused by a new subtype duck hepatitis type 1 virus
文献类型: 外文期刊
第一作者: Liu, Ming
作者: Liu, Ming;Fanyi-Meng;Li, Xiao-jun;Zhang, Zhuo;Liu, Siguo;Zhang, Yun
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关键词: monoclonal antibody;viral antigen;morbidity rate;cell necrosis;sequence alignment;vacuolation rate
期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )
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收录情况: SCI
摘要: Duck hepatitis type 1 virus (DHV-1) causes a fatal disease in ducklings but there is no report of DHV-1 isolation from goose. Recently, cases of a new disease in overfeeding geese were reported from China. The cases were characterized by haemorrhagic hepatitis lesions on liver after post mortem examinations. The flocks showed about 20-40% morbidity and less than 5% mortality. The histopathological lesions showed destroyed structure of hepatocytic tissue, severe vacuolation and necrosis of hepatocytes. Viral antigen could be detected by monoclonal antibody against duck hepatitis type 1 virus (DHV-1) in the cytoplasm of positive hepatocytes. PCR amplified viral sequences with primers specific for recent Korean-like duck hepatitis type 1 virus (DHV-1C). Alignment of the complete sequence demonstrated that the isolated JT strain from goose exhibiting 95.9% identity to DHV-1C AP-03337 strain, and only 75.3% to classical DHV-1 virus. 80% goslings developed haemorrhagic hepatitis after infection with JT strain. This is the first report on the involvement of a DHV-1 virus in goose
分类号: S8
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