Gut phageome of the giant panda (Ailuropoda melanoleuca) reveals greater diversity than relative species

文献类型： 外文期刊

第一作者： Lu, Juan

作者： Lu, Juan;Zhao, Min;Shen, Quan;Yang, Shixing;Ji, Likai;Liu, Yuwei;Wang, Xiaochun;Zhang, Wen;Wang, Haoning;Wang, Chunmei;Shan, Tongling;Hou, Rong;Liu, Songrui

作者机构：

关键词： viral metagenomics; gut phageome; diversity; giant pandas; bacteriophages

期刊名称：MSYSTEMS （ 影响因子：6.4； 五年影响因子：7.3 ）

ISSN： 2379-5077

年卷期： 2023 年

页码：

收录情况： SCI

摘要： The gut flora is a treasure house of diverse bacteriophages maintaining a harmonious and coexistent relationship with their hosts. The giant panda (Ailuropoda melanoleuca), as a vulnerable endemic species in China, has existed for millions of years and is regarded as a flagship species for biodiversity conservation. And yet, limited studies have analyzed the phage communities in the gut of giant pandas. Using viral metagenomic analysis, the phageomes of giant pandas and other relative species were investigated. Our study explored and compared the composition of phage communities from different animal sources. Giant pandas possessed more diverse and abundant phage communities in the gut compared with other relevant animals. Phylogenetic analyses based on the phage terminase large subunit (TerL) showed that the Caudovirales phages in giant pandas also presented highly genetic diversity. Our study revealed the diversity of phage communities in giant pandas and other relative species, contributing to the health maintenance of giant pandas and laying the groundwork for molecular evolution research of bacteriophages in mammals.IMPORTANCEGut phageome plays an important role in shaping gut microbiomes by direct interactions with bacteria or indirect influences on the host immune system, potentially regulating host health and disease status. The giant panda (Ailuropoda melanoleuca) is a vulnerable and umbrella species for biodiversity conservation. Our work explored and compared the gut phageome of giant pandas and relative species, contributing to the health maintenance of giant pandas. Gut phageome plays an important role in shaping gut microbiomes by direct interactions with bacteria or indirect influences on the host immune system, potentially regulating host health and disease status. The giant panda (Ailuropoda melanoleuca) is a vulnerable and umbrella species for biodiversity conservation. Our work explored and compared the gut phageome of giant pandas and relative species, contributing to the health maintenance of giant pandas.

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[1]Gut phageome of the giant panda (Ailuropoda melanoleuca) reveals greater diversity than relative species. Lu, Juan,Zhao, Min,Shen, Quan,Yang, Shixing,Ji, Likai,Liu, Yuwei,Wang, Xiaochun,Zhang, Wen,Wang, Haoning,Wang, Chunmei,Shan, Tongling,Hou, Rong,Liu, Songrui. 2023

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