Covalent conjugation with quercetin mitigates allergenicity of the bee pollen allergen Bra c p in a murine model
文献类型: 外文期刊
第一作者: Zhou, Enning
作者: Zhou, Enning;Li, Qiangqiang;Pan, Fei;Tao, Yuxiao;Li, Xiangxin;Xue, Xiaofeng;Wu, Liming;Xu, Rui
作者机构:
关键词: Bra c p; Quercetin; Covalent conjunction; Allergenicity; Purine metabolism; Calcium signaling
期刊名称:FOOD CHEMISTRY ( 影响因子:8.8; 五年影响因子:8.6 )
ISSN: 0308-8146
年卷期: 2024 年 436 卷
页码:
收录情况: SCI
摘要: Profilin family members are highly conserved food allergens that can cause widespread cross-allergic reactions. Our previous research has demonstrated that the covalent conjunction with quercetin can disrupt the conformational epitopes of a profilin allergen, Bra c p. In this study, we further investigated the intrinsic molecular mechanisms using molecular dynamics simulations. Moreover, the allergenic potential of Bra c p and its conjugate with quercetin was assessed in BALB/c mice. The results showed that continuous interaction with quercetin increased the molecular motion of Bra c p, causing changes to its alpha-helices and exposing hydrophobic residues which altered antigenic epitopes. Additionally, mice treated with Bra c p-quercetin conjugate showed reduced allergic reactions compared to those treated with Bra c p alone by regulating purine metabolism, calcium signaling, and CD4+CD25+ Tregs proportion. Quercetin conjugation decreases the allergenicity of Bra c p, providing a scientific foundation for reducing the profilin allergens in food.
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