Comprehensive evaluation of chiral sedaxane with four stereoisomers for risk reduction: Bioactivity, toxicity, and stereoselective dissipation in crop planting systems

文献类型： 外文期刊

第一作者： Di, Shanshan

作者： Di, Shanshan;Xie, Yunye;Cang, Tao;Liu, Zhenzhen;Zhao, Huiyu;Qi, Peipei;Wang, Zhiwei;Wang, Xinquan;Di, Shanshan;Cang, Tao;Liu, Zhenzhen;Zhao, Huiyu;Qi, Peipei;Wang, Zhiwei;Wang, Xinquan;Xie, Yunye;Chu, Yanyan;Wang, Xinquan

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关键词： Sedaxane stereoisomers; Fungicidal activity; Mechanism; Acute toxicity; Crop planting systems; Stereoselective dissipation

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 434 卷

页码：

收录情况： SCI

摘要： A comprehensive evaluation of chiral pesticide at the stereoisomeric level is an effective strategy to improve efficiency and reduce risk on foods. For chiral sedaxane with four stereoisomers, there were 517-1013 fold differences in bioactivity for three kinds of phytopathogens and 3.73 fold differences in toxicity against model organism (Danio rerio) between the best (trans-1R2S-sedaxane) and worst stereoisomer (cis-1S2S-sedaxane). Trans-1R2S-sedaxane had the strongest affinity with the active site than other stereoisomers, which might contribute to the highest bioactivity. Trans-sedaxane was 28.2-331 fold more effective than cis-sedaxane. The dissipation half-lives of sedaxane stereoisomers ranged from 3.28 to 30.7 d in the test crops and soils. Trans- 1S2R-sedaxane and cis-1S2S-sedaxane were preferentially dissipated in corn plants, while the preferential dissipation of trans-1R2S-sedaxane was found in wheat plants, potato plants and corn soil. The preferential dissipation of trans-sedaxane in corn plants, wheat plants, potato plants and corn soil would be environmentally friendly.

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