Human health safety studies of a new insecticide: Dissipation kinetics and dietary risk assessment of afidopyropen and one of its metabolites in cucumber and nectarine

文献类型： 外文期刊

第一作者： Ji, Mingshan

作者： Ji, Mingshan;Xie, Jun;Liu, Xingang;Dong, Fengshou;Xu, Jun;Wu, Xiaohu;Zheng, Yongquan;Zheng, Yunxi

作者机构：

关键词： Afidopyropen; Residue; Dissipation; Dietary risk assessment; UHPLC-MS/MS

期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY （ 影响因子：3.271； 五年影响因子：4.291 ）

ISSN： 0273-2300

年卷期： 2019 年 103 卷

页码：

收录情况： SCI

摘要： To preliminarily study the law of natural dissipation and the relation to human health of a new insecticide (afidopyropen), the QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method and a UHPLC-MS/MS system were used to extract and detect the afidopyropen and its metabolite (M440I007) from cucumber and nectarine. The limits of quantitation (LOQs) of both target compounds in two matrixes were reduced to 0.0001 mg/kg. Dissipative dynamics experiments indicated that afidopyropen residue dissipation is more consistent with a two-compartment kinetic model than a first-order kinetic model whether in cucumber or nectarine. The half-lives were less than 1.1 and 2.0 days in the distribution phase and up to 9.9 and 27.7 days in the elimination phase in cucumber and nectarine, respectively. The correlation coefficients were 0.9620, 0.9391, and 0.9923 for cucumber and 0.9676 and 0.9985 for nectarine from different locations. M4401007 initially increased rapidly, reached a maximum at 2 days, and then decreased gradually over time. Finally, dietary risk assessment indicated that the mixed residues of afidopyropen and M440I007 at the recommended dosage would not cause health concerns in population.

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