Genome-wide detection of copy number variations in polled yak using the Illumina BovineHD BeadChip

文献类型： 外文期刊

第一作者： Jia, Congjun

作者： Jia, Congjun;Wang, Hongbo;Li, Chen;Wu, Xiaoyun;Ding, Xuezhi;Guo, Xian;Bao, Pengjia;Pei, Jie;Chu, Min;Liang, Chunnian;Yan, Ping;Jia, Congjun;Zan, Linsen

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关键词： Polled yak; Copy number variation; Illunima BovineHD BeadChip; High altitude adaptation; Economic traits

期刊名称：BMC GENOMICS （ 影响因子：3.969； 五年影响因子：4.478 ）

ISSN： 1471-2164

年卷期： 2019 年 20 卷

页码：

收录情况： SCI

摘要： BackgroundCopy number variations (CNVs), which are genetic variations present throughout mammalian genomes, are a vital source of phenotypic variation that can lead to the development of unique traits. In this study we used the Illunima BovineHD BeadChip to conduct genome-wide detection of CNVs in 215 polled yaks.ResultsA total of 1066 CNV regions (CNVRs) were detected with a total length of 181.6Mb, comprising similar to 7.2% of the bovine autosomal genome. The size of these CNVRs ranged from 5.53kb to 1148.45kb, with an average size of 170.31kb. Eight out of nine randomly chosen CNVRs were successfully validated by qPCR. A functional enrichment analysis of the CNVR-associated genes indicated their relationship to a number of molecular adaptations that enable yaks to thrive at high altitudes. One third of the detected CNVRs were mapped to QTLs associated with six classes of economically important traits, indicating that these CNVRs may play an important role in variations of these traits.ConclusionsOur genome-wide yak CNV map may thus provide valuable insights into both the molecular mechanisms of high altitude adaptation and the potential genomic basis of economically important traits in yak.

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