The effects of dietary soybean isoflavone on immunity in Chinese yellow-feathered broilers challenged with infectious bursal disease virus

文献类型： 外文期刊

第一作者： Jiang, S. Q.

作者： Jiang, S. Q.;Jiang, Z. Y.;Chen, J. L.;Hong, P.;Chen, F.;Jiang, Z. Y.;Zhu, C.

作者机构：

关键词： Chinese Yellow-feathered broilers; immunity; infectious bursal disease virus; lymphocyte proliferation; soybean isoflavone

期刊名称：JOURNAL OF AGRICULTURAL SCIENCE （ 影响因子：1.476； 五年影响因子：1.891 ）

ISSN： 0021-8596

年卷期： 2018 年 156 卷 6 期

页码：

收录情况： SCI

摘要： To investigate the effects of soybean isoflavone (SI) on immunity in infectious bursal disease virus (IBDV)-infected broilers, chicks were fed the same basal diet supplemented with 0 (non-infected control), 0 (infected control), 10, 20 or 40 mg/kg SI for 44 days. At 21 days old, chickens were inoculated with bursal infectious dose causing 50% morbidity of the IBDV BC 6/85 strain by the eye-drop and nasal route (except for non-infected controls). Results showed that, over 1-23 days post-infection (dpi), there was a significant interaction between SI supplementation level and time: high-level SI supplementation increased peripheral T lymphocyte proliferation, percentages of CD3(+), CD4(+) and CD8(+) T lymphocytes, CD4(+) to CD8(+) ratio, serum concentrations of IgA, IgM and IgG, and IBDV antibody titres. Except for serum IgA and IgM, these variables increased over time with far higher values at 23 dpi than earlier. Compared with non-infected controls, IBDV inoculation decreased peripheral T lymphocyte proliferation at 3 dpi, percentages of CD3(+), CD4(+) and CD8(+) T lymphocytes, and serum IgG, IgM concentration at 23 dpi, and increased IBDV antibody titres at 7, 15 and 23 dpi. Supplemental SI quadratically increased peripheral T lymphocyte proliferation, CD4(+) to CD8(+) ratio and serum IgA concentration at 3 dpi, percentages of CD3(+), CD4(+) and CD8(+) T lymphocytes at 3 and 23 dpi, and serum IgM concentration and IBDV antibody titres at 23 dpi. These results indicate that dietary SI improved cellular and humoral immunity of IBDV-infected birds and may enhance resistance of Yellow-feathered broilers to infectious diseases.

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