Large-scale phylogenetic analysis reveals genetic diversity and geographic distribution of rabies virus in South-East and South Asia

文献类型： 外文期刊

第一作者： Zhang, Liang

作者： Zhang, Liang;Sun, Sheng;Gong, Wenjie;Tu, Zhongzhong;He, Biao;Liu, Yan;Tu, Changchun;Feng, Ye;Gong, Wenjie;Cruz, Jeffrey;Gonzales, Riva Marie;Thompson, Lesa;Dukpa, Kinzang;Cruz, Jeffrey;Tu, Changchun;Feng, Ye

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关键词： Rabies virus; Genetic diversity; Distribution; Phylogenetic analysis; South-East and South Asia

期刊名称：INFECTION GENETICS AND EVOLUTION （ 影响因子：3.2； 五年影响因子：3.0 ）

ISSN： 1567-1348

年卷期： 2023 年 113 卷

页码：

收录情况： SCI

摘要： South-East Asia (SEA) and South Asia (SA) are two important geographic regions with the most severe enzootic rabies in the world. In these regions, phylogenetic analysis of rabies virus (RABV) has been conducted only at a country level; the results obtained from different countries are scattered and unequal, with a non-uniform system to name RABV genotypes. Therefore, it is difficult to undertake origin-tracking and compare inter-country RABV evolution and transmission. To avoid the confusion in understanding and to generate a panoramic picture of RABV genetic diversity, distribution, and transmission in SEA and SA, the present study conducted a systematic phylogenetic analysis by combining all sequences representing 2368 RABV strains submitted to GenBank by 14 rabies endemic SEA and SA countries. The results showed that RABVs circulating in two regions were classified into four major clades and many subclades: the Asia clade is circulating only in SEA, the Indian subcontinent, and Arctic-like clades only in SA, while the Cosmopolitan clade has been detected in both regions. The results also showed a wide range of hosts were infected by divergent RABV subclades, with dogs being the major trans-mission source. However, wildlife rabies was also found to be an important issue with 6 wild carnivore species identified as potential sources of spillover risk for sylvatic rabies to humans, domestic animals, and other wild animals. Current findings indicate that the two regions have separate virus clades circulating thus indicating the absence of cross-transmission between the regions. The study emphasizes the importance of phylogenetic analysis in the regions using uniform genotyping and naming systems for rabies surveillance, to coordinate actions of member countries to eliminate dog-mediated human rabies by 2030.

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