Genomic characterization and phylogenetic analysis of Aleutian mink disease virus identified in a sudden death mink case
文献类型: 外文期刊
第一作者: Cui, Xingyang
作者: Cui, Xingyang;Cui, Xingyang;Yang, Yan;Luo, Jilong;Zhang, Ping;Ge, Junwei;Wang, Fang;Chen, Hongyan;Zhao, Lili;Zhang, Ping;Ge, Junwei;Zhao, Lili
作者机构:
关键词: Aleutian mink disease virus; Sudden death; Isolates; Genomic characterization; Phylogenetic; Feature
期刊名称:COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES ( 影响因子:2.0; 五年影响因子:2.3 )
ISSN: 0147-9571
年卷期: 2023 年 101 卷
页码:
收录情况: SCI
摘要: Aleutian mink disease (AMD) is one of the most serious diseases in minks worldwide, it brings tremendous financial losses in mink farming. AMD virus (AMDV) has unusually high genetic diversity, its genomic structure remains unclear. In 2014, sudden death of breeding minks was occurred in northeast China. After clinical signs evaluation and virus isolation, AMDV was identified in all sudden death minks, we investigated the complete genomic sequence of AMDV-LM isolated from the sudden death case. The full-genome sequence of AMDV-LM was 7 nucleotides (nts) or 8 nts longer than isolates AMDV-BJ and AMDV-G. AMDV-LM contained two unique nucleotide changes in VP2 (G79T, T710C), which led to two amino acid changes G27W and L237S. For NS1, some unique point mutations, such as A374C, A428C, A463C, and T476A were found and resulted in four unique amino acid mutations at N24V, H125P, V143P, K155Q, and V159N, respectively. The predicted secondary structure of the 5 & PRIME; terminal of AMDV-LM formed a large bubble formation near the 5 & PRIME; end, which affected the stability of the U-shaped hairpin. Phylogenetic analysis demonstrated that AMDV-LM was closely related to Chinese isolates and confirmed that AMDV strains circulating in China had different origins of ancestors. This study was first to investigate the association of sudden death of adult breeding minks with AMDV infection. Our findings provide useful suggestions for evaluation of the pathogenic potential of AMDV, additional details on AMDV genome characterization were also presented. Future work should focus on the importance of AMDV-LM strain in mink infection.
分类号:
- 相关文献
作者其他论文 更多>>
-
A screening strategy for identifying umami peptides with multiple bioactivities from Stropharia rugosoannulata using in silico approaches and SPR sensing
作者:Li, Jialin;Li, Wen;Wu, Di;Zhang, Zhong;Chen, Wanchao;Yang, Yan;Li, Jialin;Liu, Xiaofeng;Chen, Wanchao
关键词:Umami peptide; Stropharia rugosoannulata; ACE; DPP-IV; Molecular docking; SPR
-
Comparative metabolome profiling of Paris polyphylla var. yunnanensis cultivars and Paris luquanensis and their biological activity in zebrafish model
作者:Gao, Xue Mei;Tang, Li Ping;Wang, Xin;Ma, Wei Si;Yang, Yan;Yang, Bin
关键词:Paris polyphylla var. yunnanensis; Paris luquanensis; Widely targeted metabolomics; ROS; Zebrafish; Neutrophil; Toxicity
-
Effect of ?-glucosidase on the aroma of liquid-fermented black tea juice as an ingredient for tea-based beverages
作者:Liang, Shuang;Wang, Fang;Zou, Chun;Yin, Jun-Feng;Xu, Yong-Quan;Granato, Daniel;Zhong, Xiaoyu;Xiao, An-Feng;Li, Lijun;Ye, Qun
关键词:Tea aroma; Black tea juice; Liquid fermentation; β -Glucosidase; Camellia sinensis
-
PDA-PRGCN: identification of Piwi-interacting RNA-disease associations through subgraph projection and residual scaling-based feature augmentation
作者:Zhang, Ping;Sun, Weicheng;Wei, Dengguo;Li, Guodong;Xu, Jinsheng;Li, Li;Wei, Dengguo;Wei, Dengguo;Li, Li;You, Zhuhong;Zhao, Bowei
关键词:Piwi-interacting RNA; Disease; Subgraph projection; Feature augmentation; Graph convolutional network; piRNA-disease associations
-
Optimization of Submerged Culture Parameters of the Aphid Pathogenic Fungus Fusarium equiseti Based on Sporulation and Mycelial Biomass
作者:Zhao, Xueyi;Chai, Junfa;Jia, Yanxia;Wang, Fang
关键词:Fusarium equiseti; optimal submerged culture conditions; response surface methodology; box-behnken design; Myzus persicae
-
Spatial expansion paths of urban heat islands in Chinese cities: Analysis from a dynamic topological perspective for the improvement of climate resilience
作者:Qiao, Zhi;Lu, Yingshuang;He, Tong;Wu, Feng;Xu, Xinliang;Liu, Luo;Wang, Fang;Sun, Zongyao;Han, Dongrui
关键词:Land use and cover change; Spatial expansion path; Urban heat island; Urban heat island expansion index; Urban heat island intensity
-
Diversification of Sinorhizobium populations associated with Medicago polymorpha and Medicago lupulina in purple soil of China
作者:Tang, Mingxing;Wang, Haoyu;Qi, Xin;He, Teng;Zhang, Bin;Yu, Miao;Wang, Beinan;Liu, Xiaoyun;Wang, Entao;Wang, Fang;Liu, Zhongkuan
关键词:Medicago; rhizobia; diversity; phylogeny; plant host; soil nutrient