Three dimensional fibrous scaffolds as tissue repairing templates during post-operative healing

文献类型： 外文期刊

第一作者： Wang, Chenhong

作者： Wang, Chenhong;Liu, Zifan;Zhang, Nuozi;Huang, Shifen;Xu, Shanshan;Wang, Chenhong;Liu, Zifan;Zhang, Nuozi;Huang, Shifen;Han, Charles C.;Xu, Shanshan;Wang, Chenhong;Wang, Heran;Xia, Qinghua;Mao, Ruoqing;Liu, Ying;Liu, Ying;Liu, Ying

作者机构：

关键词： Electrospun scaffold; Biodegradability; Biocompatibility; Thickness

期刊名称：MATERIALS & DESIGN （ 影响因子：7.991； 五年影响因子：7.097 ）

ISSN： 0264-1275

年卷期： 2021 年 210 卷

页码：

收录情况： SCI

摘要： Electrospun scaffolds, as a kind of biomimetic and biocompatible nanomaterial, evoke much interest in tissue regeneration and organ renovation during past decades. However, it has not been illustrated about the relationship between the structural length scale of 3D scaffolds and their ability to integrating with natural tissues. In this study, using a simple post-operative adhesion model, we evaluated the effects of three kinds of fibrous scaffolds with different thicknesses (50 mu m, 120 mu m, and 200 mu m-thick scaffolds) as an ideal anti-adhesion barrier. Though having the same component, surface porosity and degradation rate, 120 mu m and 200 mu m-thick scaffolds with smaller mean pore size could prevent adhesion while 50 mu m-thick ones couldn't. The fibrous scaffolds with an insufficient thickness (50 mu m) provided a better platform for cell proliferation, which led to its highest adhesion occurrence in all the operation groups, even higher than the negative group without any anti-adhesion membranes. Meanwhile, postoperative intestinal obstruction and inflammation were emphatically discussed after considering the implantation amount, membrane flexibility, and cell toxicity. This study on 3D fibrous scaffolds during post-operative healing might open some new and interesting opportunities for understanding tissue regeneration and organ renovation, and designing multilevel hierarchical structures as implanted templates. (C) 2021 The Authors. Published by Elsevier Ltd.

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