Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan

文献类型： 外文期刊

第一作者： Zhao, Lingjun

作者： Zhao, Lingjun;Zhao, Jing;Xu, Shiyuan;Zhao, Lingjun;Dong, Zhihao;Xu, Shiyuan;Wang, Dong;Zhao, Lingjun;Zhao, Jing;Xu, Shiyuan;Dong, Zhihao;Zhao, Jing;Wang, Dong

作者机构：

关键词： Busulfan; Orchitis; Cytokines; Cytoskeleton

期刊名称：REPRODUCTIVE TOXICOLOGY （ 影响因子：3.3； 五年影响因子：3.6 ）

ISSN： 0890-6238

年卷期： 2023 年 115 卷

页码：

收录情况： SCI

摘要： Busulfan is an alkylating agent commonly used in cancer chemotherapy. It is also an ideal agent for preparing transplant recipients of spermatogonial stem cells because of its high efficiency in destroying endogenous germ cells in the testis. However, its toxicity mechanism remains unclear, affecting its clinical use and applications. Based on reports of busulfan causing orchitis and a previous study by our team, this article summarizes the relationship between busulfan and orchitis, cytokines, the blood-testis barrier, and the cytoskeleton, unravels the regulatory pathways and mechanism behind busulfan-induced orchitis, and reveals the molecular mechanism underlying impaired spermatogenic function in orchitis, providing new ideas for the clinical application of busulfan while reducing its testicular toxicity.

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