miR-193-5p negatively regulates PIK3CD to promote crop fibrocyte proliferation in pigeon (Columba livia)

文献类型： 外文期刊

第一作者： Ma, Hui

作者： Ma, Hui;Ge, Pingzhuang;Bian, Shixiong;Li, Yunlei;Ni, Aixin;Zhang, Ran;Zhao, Jinmeng;Zong, Yunhe;Yuan, Jingwei;Sun, Yanyan;Chen, Jilan

作者机构：

关键词： PIK3CD; miR-193-5p; crop fibrocyte; cell proliferation; pigeon

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2023 年 102 卷 2 期

页码：

收录情况： SCI

摘要： The crop of pigeon has specific characteris-tics as producing crop milk in the lactating period. How-ever, the exact mechanisms underlying the regulation of crop lactation remain unclear. miRNAs, the essential regu-lators of gene expression, are implicated in various physio-logical and biological activities. In this study, we discovered new miRNA that regulated phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta (PIK3CD) and crop fibrocyte proliferation. Results of the luciferase reporter assay suggested that miR-193-5p suppressed PIK3CD expression by targeting a conserved binding site in the 30-untranslated region (UTR) of PIK3CD mRNA. MiR-193-5p promoted crop fibrocyte proliferation and migration, whereas PIK3CD inhibited these effects. These findings suggested an important regulatory role of miR-193-5p in crop fibrocyte proliferation, suggesting that miR-193-5p and PIK3CD might be important regulators of crop milk production.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序