Nutritional properties and osteogenic activity of simulated digestion components and peptides from Larimichthys crocea

文献类型： 外文期刊

第一作者： Xu, Zhe

作者： Xu, Zhe;Han, Shiying;Han, Lingyu;Li, Tingting;Xu, Zhe;Tan, Zhijian;Xu, Zhe;Tan, Zhijian;Chen, Hui;Du, Ming;Dong, Xiufang;Tu, Maolin

作者机构：

关键词： Larimichthys crocea; Digestion; Protein; Osteoblasts; Function

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：8.1； 五年影响因子：7.7 ）

ISSN： 0963-9969

年卷期： 2023 年 163 卷

页码：

收录情况： SCI

摘要： Fish provides a range of health benefits due to its nutritional and bioactive components. However, the bioactive peptides derived from Larimichthys crocea proteins were not fully investigated, especially the beneficial effects related to bone growth in vitro. In this study, the water extract protein was subjected to the simulated in vitro digestion process, and the osteogenic effect of enzymatic hydrolysate at different digestion stages was evaluated by the proliferation of osteoblast. The protein hydrolyzates of group pepsin treatment for 1 h and pepsin treatment for 2 h showed higher osteogenic activity in vitro. Two peptides including IERGDVVVQDSPSD from pepsin treatment for 1 h and RGDLGIEIPTEK from pepsin treatment for 2 h were identified, which revealed eminent effects in terms of promoting osteoblast proliferation and enhancing ALP activity. Moreover, the available nutrients in the proteins were determined by the molecular weight distribution and free amino acid composition. Those peptides also showed stronger interaction with RGD than integrins. Therefore, the peptides from Larimichthys crocea can be used as an effective ingredient for promoting bone growth in the future.

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