Saponins from Momordica charantia exert hypoglycemic effect in diabetic mice by multiple pathways
文献类型: 外文期刊
第一作者: Deng, Yuanyuan
作者: Deng, Yuanyuan;Zhang, Yan;Liu, Guang;Zhou, Pengfei;Li, Ping;Zhao, Zhihao;Zhang, Ruifen;Tang, Xiaojun;Wei, Zhencheng;Zhang, Mingwei;Wang, Zhangying;Wei, Zhencheng;Zhang, Mingwei
作者机构:
关键词: hypoglycemic effects; mice; Momordica charantia; pathways; saponin
期刊名称:FOOD SCIENCE & NUTRITION ( 影响因子:3.9; 五年影响因子:4.1 )
ISSN: 2048-7177
年卷期: 2023 年
页码:
收录情况: SCI
摘要: The antidiabetic activity of saponins extracted from Momordica charantia (MCS) on streptozotocin-induced diabetic mice was investigated in order to elucidate the mechanism of MCS for exerting hypoglycemic effects. Saponins were first extracted from M. charantia L. and their composition was analyzed. The diabetic Kunming mice were fed low-dose saponins from M. charantia L. and high-dose MCS, using normal mice and diabetic mice as controls. Body weight, blood glucose level, oral glucose tolerance, serum C-peptide level, hepatic antioxidant capacity, hepatic glycogen and hexokinase in liver tissues, serum blood lipid level, and alpha-glucosidase activity in small intestines were measured, and microstructure of pancreatic islet was analyzed. The results showed that the total content of seven triterpenoid compounds in MCS was 18.24 mu g/ mg, with Momordicoside K having the highest content at 11.66 mu g/mg. Diabetic mice treated with MCS at 100 and 200 mg/kg body weight daily for 30 days showed a maximum glucose reduction (p <.05) of 12.63% and 26.47%, respectively. MCS significantly decreased levels of postprandial hyperglycemia, serum lipid, alpha-glucosidase activity, and liver malondialdehyde. Additionally, levels of serum C-peptide and liver glycogen, as well as hexokinase and antioxidant enzyme activity, were significantly increased compared to the diabetic control groups. Histopathological results showed that MCS markedly reduced degenerative changes in islet beta-cells. It is concluded that MCS exerts antidiabetic effects by improved hypoglycemic, hypolipidemic, and antioxidant effects, increased hexokinase activity and glycogen synthesis, and enhanced reparative effects on the histological architecture and insulin secretion function of the pancreas.
分类号:
- 相关文献
作者其他论文 更多>>
-
Fibrous whey protein mediated homogeneous and soft-textured emulsion gels for elderly: Enhancement of bioaccessibility for curcumin
作者:Wang, Zhiming;Deng, Yuanyuan;Zhang, Yan;Tang, Xiaojun;Zhou, Pengfei;Li, Ping;Zhao, Zhihao;Liu, Guang;Zhang, Mingwei;Wang, Zhiming;Zhang, Mingwei;Zhang, Mingwei;Wang, Zhangying
关键词:Protein self-assembly aggregates; Oil-water state; Texture properties; Gelation dynamic; Macrophase separation
-
Selective adsorption of volatile compounds of oyster peptides by V-type starch for effective deodorization
作者:Dai, Yaolin;Ren, Zhongyang;Zhang, Yucang;Weng, Wuyin;Shi, Linfan;Li, Ping;Ren, Zhongyang;Weng, Wuyin;Shi, Linfan
关键词:V-type starch; Oyster peptide; Off-odors; Selective adsorption; Deodorization
-
TMT-based proteomic and transcriptomic analysis reveal new insights into heat stress responsive mechanism in edible mushroom Grifola frondosa
作者:Xie, Hongyan;Wan, Luzhang;Han, Jiandong;Huang, Chunyan;Li, Jin;Yao, Qiang;Yang, Peng;Gong, Zhiyuan;Zhang, Yan;Yu, Hao
关键词:Grifola frondosa; Proteomics; Heat stress response; Transcriptomics; Heat shock protein
-
Semi-closed synthesis of mesoporous carbon supported metal oxide nanoparticles
作者:Xing, Chen;Zhang, Shiguo;Zhang, Yan;Xing, Chen;Tan, Zhijian
关键词:Semi-closed synthesis; Mesoporous carbon; Metal oxide nanoparticle; Selective aqueous oxidation
-
Enhancement of water barrier and antimicrobial properties of chitosan/gelatin films by hydrophobic deep eutectic solvent
作者:Wen, Haitao;Liu, Zhongyi;Wen, Haitao;Tang, Daobang;Lin, Yaosheng;Zou, Jinhao;Zhou, Pengfei;Wang, Xuping
关键词:Chitosan; gelatin film; Hydrophobic deep eutectic solvent; Antimicrobial activity; Thymol; Food packaging
-
Gut microbial fermentation promotes the intestinal anti-inflammatory activity of Chinese yam polysaccharides
作者:Bai, Yajuan;Wang, Fengzhong;Bai, Yajuan;Zhang, Ruifen;Chen, Yanxia;Zhang, Mingwei;Zhou, Yue;Bai, Yajuan;Wang, Fengzhong;Wang, Fengzhong;Zhang, Mingwei
关键词:Chinese yam polysaccharide; Digestion and fermentation; Polysaccharide -gut microbiota interaction; Anti-inflammatory effect; Intestinal barrier; Prebiotic effect
-
Insight into muscle quality of white shrimp (Litopenaeus vannamei) frozen with static magnetic-assisted freezing at different intensities
作者:Sun, Qinxiu;Zhang, Honghong;Hou, Qian;Zhang, Yan;Su, Jiangpeng;Liu, Xianhua;Wei, Qihang;Ji, Hongwu;Liu, Shucheng;Yang, Xianqing;Sun, Qinxiu;Liu, Shucheng;Dong, Xiuping
关键词:White shrimp; Magnetic field-assisted immersion freezing; Muscle quality; Ice crystal