New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets
文献类型: 外文期刊
第一作者: Zhang, Feng
作者: Zhang, Feng;Chen, Mengxian;Liu, Xiaodan;Li, Shenghe;Jin, Erhui;Zhang, Feng;Li, Shenghe;Jin, Erhui;Ji, Xu
作者机构:
关键词: Weaned piglet; Endoplasmic reticulum stress; Unfolded protein response; Anterior gradient 2; Intestinal barrier function
期刊名称:ANIMAL NUTRITION ( 影响因子:6.3; 五年影响因子:6.9 )
ISSN: 2405-6383
年卷期: 2023 年 15 卷
页码:
收录情况: SCI
摘要: Sustained dysfunction of the intestinal barrier caused by early weaning is a major factor that induces postweaning diarrhea in weaned piglets. In both healthy and diseased states, the intestinal barrier is regulated by goblet cells. Alterations in the characteristics of goblet cells are linked to intestinal barrier dysfunction and inflammatory conditions during pathogenic infections. In this review, we summarize the current understanding of the mechanisms of the unfolded protein response (UPR) and anterior gradient 2 (AGR2) in maintaining intestinal barrier function and how modifications to these systems affect mucus barrier characteristics and goblet cell dysregulation. We highlight a novel mechanism underlying the UPR-AGR2 pathway, which affects goblet cell differentiation and maturation and the synthesis and secretion of mucin by regulating epidermal growth factor receptor and mucin 2. This study provides a theoretical basis and new insights into the regulation of intestinal health in weaned piglets.(c) 2023 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
分类号:
- 相关文献
作者其他论文 更多>>
-
Dual-use ionization source for direct and sensitive detection of trace carbamates residue
作者:Liu, Tong;Mu, Guodong;He, Muyi;Chen, Fengming;Xu, Xiuli;Zhang, Feng;Liu, Tong;He, Muyi;Chen, Fengming;Xu, Xiuli;Zhang, Feng;Mu, Guodong
关键词:Graphene oxide; Molecularly imprinted technique; Steel sheet spray; Carbamate
-
Tritrophic Interactions among Arthropod Natural Enemies, Herbivores and Plants Considering Volatile Blends at Different Scale Levels
作者:Ali, Muhammad Yasir;Zhang, Jinping;Zhang, Feng;Ali, Muhammad Yasir;Liu, Tongxian;Ali, Muhammad Yasir;Ali, Muhammad Yasir;Zhang, Jinping;Zhang, Feng;Naseem, Tayyaba;Holopainen, Jarmo K. K.
关键词:biological control; indirect defense; insect herbivores; natural enemies; plant volatiles
-
Sustainable intensification with irrigation raises farm profit despite climate emergency
作者:Muleke, Albert;Harrison, Matthew Tom;Eisner, Rowan;Liu, Ke;de Voil, Peter;Yanotti, Maria;Monjardino, Marta;Yin, Xiaogang;Nie, Jiangwen;Yin, Xiaogang;Nie, Jiangwen;Wang, Weilu;Ferreira, Carla;Ferreira, Carla;Ferreira, Carla;Ferreira, Carla;Zhao, Jin;Zhang, Feng;Fahad, Shah;Shurpali, Narasinha;Forster, Daniel;Feng, Puyu;Zhang, Yunbo;Yang, Rui;Qi, Zhiming;Qi, Zhiming;Fei, Wang
关键词:adaptation; climate crisis; climate emergency; food economic security; grain; infrastructure; irrigation; water
-
Responses of grassland productivity to mowing intensity and precipitation variability in a temperate steppe
作者:Zhang, Feng;Zhang, Bin;Zhao, Tianqi;Zhao, Mengli;Han, Guodong;Bennett, Jonathan A.;Zhao, Tianqi;Zhao, Tianqi;Bai, Keyu;Bai, Keyu
关键词:Mowing; Precipitation; Graminoids; Forbs; Legacies
-
Interaction of genotype-ecological type-plant spacing configuration in sorghum [Sorghum bicolor (L.) Moench] in China
作者:Yan, Peng;Gao, Fang-Chao;Qi, Dan-Dan;Wang, Zhi;You, Guang-Xia;Han, Fen-Xia;Li, Gui-Ying;Song, Ying-Hui;Li, Jun-Xia;Zhang, Kuang-Ye;Ke, Fu-Lai;Zhang, Feng;Tang, Yu-Jie;Wang, Nai;Li, Ji-Hong;Gao, Yue;Yang, Wei;Zhou, Zi-Yang;Zhao, Xiang-Na;Gao, Feng-Ju
关键词:sorghum; genotype-environment-management interaction; plant space configuration; variety introduction; ecological type
-
Sinking Behavior of Netting Panels Made with Various Twine Materials, Solidity Ratios, Knot Types, and Leadline Weights in Flume Tank
作者:Shan, Chenxu;Tang, Hao;Thierry, Nyatchouba Nsangue Bruno;Zhang, Feng;Zhu, Meixi;Zhang, Can;Xu, Liuxiong;Tang, Hao;Xu, Liuxiong;Tang, Hao;Xu, Liuxiong;Tang, Hao;Xu, Liuxiong;Tang, Hao;Xu, Liuxiong;Liu, Wei;Hu, Fuxiang
关键词:netting; sinking speed; leadline weight; solidity ratio; flume tank experiment
-
Exploration of Candidate Genes Involved in the Biosynthesis, Regulation and Recognition of the Male-Produced Aggregation Pheromone of Halyomorpha halys
作者:Wu, Chunyan;Li, Fengqi;Zhang, Feng;Zhang, Jinping;Dewer, Youssef
关键词:Halyomorpha halys; aggregation pheromone; biosynthesis; terpene synthases (TPS)