A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-? production through sponging miR-221-5p

文献类型： 外文期刊

第一作者： Chen, Wei

作者： Chen, Wei;Liu, Wensen;Chang, Ying;Xu, Na;Sun, Chengbiao;Dong, Mingxin;Zhao, Na;Wang, Yan;Zhang, Jianxu;Liu, Wensen;Xu, Meng

作者机构：

关键词： CircNLRP3; Ricin toxin; MiR-221-5p; TNF-?

期刊名称：TOXICON （ 影响因子：2.8； 五年影响因子：2.8 ）

ISSN： 0041-0101

年卷期： 2023 年 224 卷

页码：

收录情况： SCI

摘要： Acting as microRNA (miRNA) sponges, circular RNAs (circRNAs) have been discovered to be critical modulators of inflammatory processes. Ricin Toxin (RT) is highly toxic to mammalian cells and low doses of RT can induce acute inflammation. However, current researches on the underlying mechanism and function of circRNA/miRNA network in RT-induced inflammation are limited. Previously, we found miR-221-5p was aberrant and associated with the inflammation of RT induction. In this study, based on the circRNA high-throughput sequencing (circRNA-seq), we obtained a novel circRNA termed circNLRP3 and revealed that circNLRP3 can sponge miR221-5p, release its target mRNA A20, and further suppress NF-kappa B signaling pathway to alleviated RT-induced TNF-alpha production. Our findings elucidated a possible mechanistic link between the circNLRP3/miR-221-5p/ A20 axis and RT-induced inflammatory response, which may broaden our understanding of RT poisoning.

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