5 '-tRF-GlyGCC promotes breast cancer metastasis by increasing fat mass and obesity-associated protein demethylase activity
文献类型: 外文期刊
第一作者: Chen, Fang
作者: Chen, Fang;Song, Chengchuang;Meng, Fantong;Zhu, Yuhua;Chen, Xi;Fang, Xingtang;Wang, Yanhong;Zhang, Chunlei;Song, Chengchuang;Chen, Xi;Fang, Xingtang;Wang, Yanhong;Zhang, Chunlei;Zhu, Yuhua;Ma, Daifu
作者机构:
关键词: 5?-tRF-GlyGCC; BC; m6A; Autophagy; Tumor metastasis
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:8.025; 五年影响因子:7.626 )
ISSN: 0141-8130
年卷期: 2023 年 226 卷
页码:
收录情况: SCI
摘要: tRNA-derived fragments (tRFs) are a class of regulatory non-coding RNAs that play essential biological functions in cancer and stress-induced diseases. Several lines of evidence suggest that 5 '-tRF-GlyGCC participates in tumor progression; however, its molecular mechanisms remain unclear. In this study, we explored the function of 5 '- tRF-GlyGCC in breast cancer (BC) progression and studied the related potential molecular mechanisms. 5 '-tRF-GlyGCC expression increased in human BC, and it promoted the proliferation, migration, and invasion of BC cells in vitro and tumor growth and metastasis in vivo. 5 '-tRF-GlyGCC was found for the first time to bind directly to fat mass and obesity-associated proteins, and increase the activity of FTO demethylase, reducing eIF4G1 methyl-ation, inhibiting autophagy, and promoting BC proliferation and metastasis. These findings suggest that 5 '-tRF-GlyGCC might be a therapeutic target for treating BC.
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