Polysaccharides from steam-processed Polygonatum cyrtonema Hua protect against d-galactose-induced oxidative damage in mice by activation of Nrf2/HO-1 signaling
文献类型: 外文期刊
第一作者: Teng, Huanhuan
作者: Teng, Huanhuan;Zhang, Yi;Jin, Chuanshan;Wang, Tongsheng;Xie, Songzi;Wu, Deling;Xu, Fengqing;Huang, Shengzhuo;Li, Lei;Xu, Fengqing
作者机构:
关键词: Polygonatum cyrtonema Hua polysaccharides; steam processing; antioxidant; oxidative damage; Nrf2; HO-1
期刊名称:JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE ( 影响因子:4.125; 五年影响因子:4.096 )
ISSN: 0022-5142
年卷期: 2023 年 103 卷 2 期
页码:
收录情况: SCI
摘要: BACKGROUND Polygonatum cyrtonema Hua is cultivated for its edible and medical value. The steam-processed rhizome of P. cyrtonema is the main form for daily consumption and it has been used traditionally in tonics for treating various age-related disorders. The aim of our study was to compare the physicochemical properties and antioxidant activity of polysaccharides respectively extracted from crude P. Cyrtonema (PCPC), and steam-processed P. cyrtonema (PCPS), and to explore a possible underlying antioxidant mechanism. RESULTS The PCPC with a molecular weight of 4.35 x 10(3) Da mainly consisted of fructose and trace amounts of glucose, whereas PCPS with 4.24 x 10(4) Da was composed of fructose, arabinose, glucose, xylose, mannose, galacturonic acid and glucuronic acid. The PCPC had a triple-helical conformation whereas PCPS was a random coil. Both exhibited free radicals- scavenging activity in vitro. In a mouse model of oxidative damage, PCPC or PCPS treatment significantly reversed histopathological alterations, reactive oxygen species (ROS) accumulation and the reduction of antioxidant enzyme activity. They both also promoted Nrf2 nuclear transport by decreasing Keap-1 expression and increasing HO-1 expression. Both in vitro and in vivo, PCPS exhibited more potent antioxidant activity than PCPC. CONCLUSION Overall, the results suggest that PCPS has a stronger effect on the prevention of oxidative damage by activating Nrf2/HO-1 antioxidant signaling. This study demonstrates the role of steam-processed P. cyrtonema rhizome and provides valuable perspective for PCPS as a functional agent. (c) 2022 Society of Chemical Industry.
分类号:
- 相关文献
作者其他论文 更多>>
-
Aroma characteristics of flaxseed milk via GC-MS-O and odor activity value calculation: Imparts and selection of different flaxseed varieties
作者:Yue, Yang;Wang, Chao;Yue, Yang;Chen, Yashu;Zheng, Mingming;Zhang, Yi;Deng, Qianchun;Zhou, Qi
关键词:Flaxseed milk; Stabilities; Sensory analysis; Stir bar sorptive extraction; Key aroma-active compounds
-
Guvermectin Biosynthesis Revealing the Key Role of a Phosphoribohydrolase and Structural Insight into the Active Glutamate of a Noncanonical Adenine Phosphoribosyltransferase
作者:Liu, Chongxi;Wang, Zhiyan;Li, Lei;Bai, Lu;Wang, Xiangjing;Liu, Chongxi;Wang, Zhiyan;Chen, Yin;Yan, Yijun;Wang, Yong-Jiang;Huang, Sheng-Xiong;Bai, Lu;Li, Shanshan;Zhang, Yanyan;Xiang, Wensheng
关键词:
-
Recent Developments in Molecular Characterization, Bioactivity, and Application of Arabinoxylans from Different Sources
作者:Pang, Jinxin;Zhang, Yi;Tong, Xiaoyang;Kong, Fanjun;Qiao, Yongjin;Pang, Jinxin;Zhong, Yaoguang;Kong, Fanjun;Tong, Xiaoyang;Li, Dan;Liu, Xifan
关键词:arabinoxylan; molecular identity; biological activity; applications; products
-
Bayesian model averaging to improve the yield prediction in wheat breeding trials
作者:Fei, Shuaipeng;Chen, Zhen;Fei, Shuaipeng;Li, Lei;Xiao, Yonggui;Fei, Shuaipeng;Ma, Yuntao
关键词:Wheat yield; Remote sensing; Hyperspectral reflectance; Bayesian model averaging; Machine learning
-
A novel and controllable method for simultaneous preparation of human milk fat substitutes (OPL, OPO and LPL): two-step enzymatic ethanolysis-esterification strategy
作者:Li, Yali;Zhang, Yi;Zhang, Yufei;Zheng, Mingming;Zhou, Yibin
关键词:Human milk fat substitutes (HMFS); Structured triacylglycerol; Immobilization enzyme; Candida sp; lipase (CSL); 2-monopalmitoylglycerol; Acyl migration
-
Co-occurrence network of microbial communities affected by application of anaerobic fermentation residues during phytoremediation of ionic rare earth tailings area
作者:Chen, Liumeng;Zhang, Yi;Kong, Xiaoying;Wang, Shujia;Li, Lianhua;Wang, Fei;Sun, Yongmin;Chen, Liumeng;Chen, Shasha;Long, Yun;Xu, An
关键词:Rare earth tailings; Anaerobic fermentation residues; Phytoremediation; Microbial community; Co -occurrence network
-
Early Identification and Localization Algorithm for Weak Seedlings Based on Phenotype Detection and Machine Learning
作者:Xu, Shengyong;Zhang, Yi;Dong, Wanjing;Xu, Shengyong;Zhang, Yi;Dong, Wanjing;Xu, Shengyong;Zhang, Yi;Dong, Wanjing;Xu, Shengyong;Zhang, Yi;Dong, Wanjing;Bie, Zhilong;Huang, Yuan;Bie, Zhilong;Huang, Yuan;Peng, Chengli
关键词:strong seedling model; phenotype measurement; machine learning; grow prediction