The behavior and mechanism of a temperature-responsive ionic liquid and its applications in extracting geniposidic acid from Eucommia ulmoides male flowers

文献类型： 外文期刊

第一作者： Wang, Yicong

作者： Wang, Yicong;Wang, Shanshan;Qin, Zongkui;Lei, Tian;Liu, Leilei;Tan, Zhijian;Tan, Zhijian

作者机构：

关键词： Temperature -responsive ionic liquids; Lower critical solution temperature; Geniposidic acid; Extraction and separation; Eucommia ulmoides male flowers

期刊名称：JOURNAL OF MOLECULAR LIQUIDS （ 影响因子：6.0； 五年影响因子：5.6 ）

ISSN： 0167-7322

年卷期： 2023 年 377 卷

页码：

收录情况： SCI

摘要： A lower critical solution temperature responsive ionic liquid (IL) was fabricated via the neutralization reaction of tetrabutyl phosphine hydroxide ([P4444]OH) and benzimidazole (BzIm) for the ultrasonic extraction of geniposide acid (GPA) from Eucommia ulmoides Male flowers. Temperature-dependence properties of this IL were closely related to its N and P atoms and self-aggregation. GPA extraction was performed to obtain a maximum extraction yield (Y = 0.23 mg/g). The experimental conditions such as IL concentration, solid-liquid ratio, temperature, time, and ultrasonic power were optimized. The sepa-ration data showed that the recovery yield (R) and distribution coefficient (K) of GPA in aqueous phase were 91.95% and 3.29, respectively. The simple treated IL could be reused for 5 times for extracting, and RGPA and RIL values were decreased to 87.18% and 78.00%, respectively, indicating that this IL had a nice reusability. Molecular dynamics simulation revealed that H-bonds of [BzIm]-/H2O molecules were seriously destroyed at high temperatures, which was the major driving force for the spontaneous aggre-gation and liquid-liquid demixing of IL/H2O system. Further, additional H-bonds were generated of GPA and water, prompting the majority of GPA to be enriched in H2O-rich phase. Thus, [P4444][BzIm]/water system is a greenly reusable potential solvent for natural GPA extraction, and these findings are meaning-ful to further promote the excavation and application of analogous ILs.(c) 2023 Elsevier B.V. All rights reserved.

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