文献类型： 外文期刊

作者： Zhao, Li ¹ ; Liu, Yonghong ¹ ; Zhi, Yu ³ ; Huang, Jintian ¹ ; Wang, Wenlong ⁴ ; Gao, Wa ⁴ ; Ding, Yulin ¹ ; Liu, Shuying ¹ ; Wang, Jinling ¹ ;

作者机构： 1.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot, Inner Mongolia, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Clin Diag & Treatment Technol Anim Dis, Hohhot, Inner Mongolia, Peoples R China

3.Inner Mongolia Acad Agr & Anim Husb Sci, Hohhot, Inner Mongolia, Peoples R China

4.Hetao Coll, Dept Med, Inner Mongolia Key Lab Tick Borne Zoonot Infect D, Bayan Nur, Inner Mongolia, Peoples R China

关键词： China; Himalayan black bears; immunohistochemistry; pathology; T-cell lymphoma

期刊名称：JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION （ 影响因子：1.569； 五年影响因子：1.647 ）

ISSN： 1040-6387

年卷期： 2023 年 35 卷 1 期

页码：

收录情况： SCI

摘要： A 12-y-old Himalayan black bear suddenly developed depression, anorexia, cough, and dyspnea and died at the Ordos Zoo, China. At autopsy, the mesenteric and cranial mediastinal lymph nodes (LNs) were enlarged; the largest cranial mediastinal LN was similar to 13 cm in diameter. Scattered-to-diffuse, rounded-or-oval, gray, firm 1-6-mm nodules were observed on the surfaces of the spleen, liver, lungs, and small intestine. Histologically, the enlarged cranial mediastinal and mesenteric LNs, spleen, small intestine, lungs, and liver contained dense populations of neoplastic lymphoid cells (NLCs). The NLCs were round-or-oval with small amounts of mildly eosinophilic cytoplasm and round-or-oval hyperchromatic nuclei with indistinct nucleoli; the mitotic count was 55 in 2.37 mm(2). Immunohistochemically, cell membranes and the cytoplasm of NLCs were CD3+, CD79a-, CD20-, CD15-, CD30-, and CD45RA-; hence, the NLCs were derived from T lymphocytes. To our knowledge, T-cell lymphoma has not been reported previously in a Himalayan black bear.