Effects of in vitro fermentation of Atractylodes chinensis (DC.) Koidz. polysaccharide on fecal microbiota and metabolites in patients with type 2 diabetes mellitus
文献类型: 外文期刊
作者: Zhang, Xin 1 ; Ma, Qian 1 ; Jia, Lina 1 ; He, Hongpeng 1 ; Zhang, Tongcun 1 ; Jia, Weiguo 3 ; Zhu, Liying 4 ; Qi, Wei 1 ; Wang, Nan 1 ;
作者机构: 1.Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China
2.Minist Educ & Tianjin, Key Lab Ind Fermentat Microbiol, Tianjin 300457, Peoples R China
3.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Natl Clin Res Ctr Geriatr, Chengdu 610041, Peoples R China
4.Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310021, Peoples R China
关键词: Type 2 diabetes mellitus; Fecal microbiota; Metabolites; Atractylodes chinensis (DC.) Koidz.
期刊名称:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES ( 影响因子:8.2; 五年影响因子:7.8 )
ISSN: 0141-8130
年卷期: 2023 年 253 卷
页码:
收录情况: SCI
摘要: Atractylodes chinensis (DC.) Koidz. polysaccharide (AKP) has been shown to have hypoglycemic activity. In this study, the effects of AKP on fecal microbiota and metabolites in healthy subjects and patients with type 2 diabetes mellitus (T2DM) were investigated using an in vitro simulated digestive fermentation model. AKP were isolated and purified from Atractylodes chinensis (DC.) Koidz. Its main component AKP1 (AKP-0 M, about 78 % of AKP) has an average molecular weight of 3.25 kDa with monosaccharide composition of rhamnose, arabinose, and galactosamine in a molar ratio of 1: 1.25: 2.88. Notably, AKP fermentation might improve the intestinal microbiota of T2DM patients by the enrichment of some specific bacteria rather than the increase of microbial diversity. The addition of AKP specifically enriched Bifidobacteriaceae and weakened the proportion of Escherichia-Shigella. Moreover, AKP also increased the levels of short-chain fatty acids without affecting total gut gas production, suggesting that AKP could have beneficial effects while avoiding flatulence. Metabolomic analysis revealed that ARP fermentation caused changes in some metabolites, which were mainly related to energy metabolism and amino acid metabolism. Importantly, ARP fermentation significantly increased the level of myo-inositol, an insulin sensitizer. In addition, a significant correlation was observed between specific microbiota and differential metabolites. This study has laid a theoretical foundation for AKP application in functional foods.
- 相关文献
作者其他论文 更多>>
-
Potential of globally distributed topsoil mid-infrared spectral library for organic carbon estimation
作者:Hong, Yongsheng;Hong, Yongsheng;Sanderman, Jonathan;Hengl, Tomislav;Chen, Songchao;Wang, Nan;Xue, Jie;Shi, Zhou;Zhuo, Zhiqing;Peng, Jie;Li, Shuo;Chen, Yiyun;Liu, Yaolin;Mouazen, Abdul Mounem;Mouazen, Abdul Mounem
关键词:Soil monitoring; Mid-infrared spectroscopy; Soil spectral library; Fractional-order derivative; Deep learning
-
Exploring the mechanism of probiotics in enhancing the utilization of chemical components (or polyphenols) of grape seed extract
作者:Xu, Lei;Li, Xiaoqiong;Zhu, Liying;Wang, Xin;Li, Jinjun;Xu, Lei;Sun, Haibiao;Liao, Jiahao;Xu, Benhong;Li, Liang;Ze, Xiaolei
关键词:In vitro fermentation; Grape seed extract; Gut microbiota; Compound probiotics; High-performance liquid chromatography; 16S rRNA sequencing
-
The positive correlation of antioxidant activity and prebiotic effect about oat phenolic compounds
作者:Zhang, Yunzhen;Li, Yueqin;Zhang, Xin;Wu, Zufang;Liu, Lianliang;Ren, Xiaxia
关键词:Oat phenolic compound; Antioxidant activity; Prebiotic effects; Fluorescence in situ hybridization (FISH); Gut microbiota
-
Biodegradation of sulfametoxydiazine by Alcaligenes aquatillis FA: Performance, degradation pathways, and mechanisms
作者:Du, Yuqian;Zhang, Xin;Du, Yuqian;Cheng, Qilu;Liu, Yangzhi;Wang, Feng;Ma, Junwei;Lin, Hui;Qian, Mingrong
关键词:Sulfonamide antibiotic; Biodegradation; Genomics; Transcriptome; Degradation product
-
Preparation and activity evaluation of angiotensin-I converting enzyme inhibitory peptides from protein hydrolysate of mulberry leaf
作者:Chen, Yu;Jiao, Yingchun;Chen, Yu;Zhang, Yu;Qi, Qianhui;Liang, Feng;Li, Xue;Sun, Suling;Wang, Xinquan;Wang, Wei;Zhang, Yu;Li, Xue;Zhang, Yu;Li, Xue;Liang, Feng;Wang, Nan;Chen, Qihe;Bai, Kaiwen;Wang, Wei
关键词:mulberry leaf protein; hydrolysate; angiotensin-I converting enzyme (ACE); inhibitory peptides; molecular docking
-
Effects of Extruded Corn with Different Gelatinization Degrees on Feed Preference, Growth Performance, Nutrient Digestibility, and Fecal Microbiota of Weaning Piglets
作者:Deng, Bo;Wu, Jie;Tao, Xin;Qi, Keke;Xu, Ziwei;Liu, Xuan;Ma, Qian;Diao, Xinping
关键词:extrusion; corn gelatinization; choice feeding; palatability; growth rate; fecal microbiota; piglets
-
Improving model parsimony and accuracy by modified greedy feature selection in digital soil mapping
作者:Zhang, Xianglin;Chen, Songchao;Zhang, Xianglin;Chen, Songchao;Wang, Nan;Xiao, Yi;Chen, Qianqian;Hong, Yongsheng;Shi, Zhou;Xue, Jie;Zhou, Yin;Teng, Hongfen;Hu, Bifeng;Zhuo, Zhiqing;Ji, Wenjun;Huang, Yuanfang;Gou, Yuxuan;Richer-de-Forges, Anne C.;Arrouays, Dominique
关键词:Digital soil mapping; Variable selection; Quantile regression forests; Computation efficiency; Northeast and North China