Si-rhodamine fluorescent probe for monitoring of hypochlorous acid in the brains of mice afflicted with neuroinflammation
文献类型： 外文期刊
作者： Liang, Fanghui 1 ; Jiang, Jian 1 ; Yang, Xinyue 2 ; Zhang, Guoyang 1 ; Zhou, Jiaying 1 ; Han, Jiahao 1 ; Geng, Yujie 1 ; Wang, Zhuo 1 ;
作者机构： 1.Beijing Univ Chem Technol, Coll Chem, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China
2.Xinjiang Acad Agr Sci, Inst Agr Qual Stand & Testing Technol, Urumqi 830000, Peoples R China
期刊名称：CHEMICAL COMMUNICATIONS （ 影响因子：4.9； 五年影响因子：4.9 ）
ISSN： 1359-7345
年卷期： 2023 年 59 卷 10 期
页码：
收录情况： SCI
摘要： Neuroinflammation leads to a persistent oxidative stress in the brain, and is closely related to the pathology of various neurological disorders. Hypochlorous acid (HClO) is a reactive oxygen species (ROS) that, at high levels, can cause brain tissue damage and neurogenic apoptosis. Herein, we designed and synthesized a silicon-rhodamine (SiR)-based formohydrazide (FH)-containing fluorescent probe, denoted as SiR-FH, for sensing HClO. This probe showed good selectivity, rapid response and high sensitivity. SiR-FH was successfully used to detect endogenous and exogenous HClO in living cells. Moreover, SiR-FH realized real-time monitoring of change in HClO flux in the brains of mice with LPS-induced neuroinflammation. The probe provides a practical tool for the monitoring of oxidative stress related to neuroinflammation.
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