Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications
文献类型： 外文期刊
作者： Yu, Mingjing 1 ; Hu, Shilong 1 ; Tang, Biao 2 ; Yang, Hua 2 ; Sun, Dongchang 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Qual & Stand Agroprod, Hangzhou 310021, Zhejiang, Peoples R China
关键词： Escherichia coli Nissle 1917; Living therapeutics; CRISPR-Cas; Light-controlled gene expression; 'Suicide' systems; Minicells; Bacterial ghosts
期刊名称：BIOTECHNOLOGY ADVANCES （ 影响因子：16.0； 五年影响因子：16.8 ）
ISSN： 0734-9750
年卷期： 2023 年 67 卷
页码：
收录情况： SCI
摘要： Genetically engineered microbes, especially Escherichia coli, have been widely used in the biosynthesis of proteins and metabolites for medical and industrial applications. As a traditional probiotic with a well-established safety record, E. coli Nissle 1917 (EcN) has recently emerged as a microbial chassis for generating living therapeutics, drug delivery vehicles, and microbial platforms for industrial production. Despite the availability of genetic tools for engineering laboratory E. coli K-12 and B strains, new genetic engineering systems are still greatly needed to expand the application range of EcN. In this review, we have summarized the latest progress in the development of genetic engineering systems in EcN, as well as their applications in the biosynthesis and delivery of valuable small molecules and biomacromolecules of medical and/or industrial interest, followed by a glimpse of how this rapidly growing field will evolve in the future.
- 相关文献
作者其他论文 更多>>
-
Quantitative characterization and dynamics of bacterial communities in ready-to-eat chicken using high-throughput sequencing combined with internal standard-based absolute quantification
作者：Yi, Zhengkai;Qiu, Mengjia;Xiao, Xingning;Ma, Jiele;Yang, Hua;Wang, Wen;Qiu, Mengjia
关键词：High-throughput sequencing; Internal standard method; Ready-to-eat chicken; Absolute abundance
-
Combining nanoflares biosensor and mathematical resolution technique for multi-class mycotoxin analysis in complex food matrices
作者：Ji, Xiaofeng;Xiao, Yingping;Wang, Wen;Lyu, Wentao;Yang, Hua;Liu, Zhi;Xi, Yang;Wang, Tong;Qi, Zuo
关键词：Nanoflares; Mycotoxins; Multispectral resolution; Second -order calibration; Food safety control
-
Evaluation of Alternaria toxins in fruits, vegetables and their derivatives marketed in China using a QuEChERS method coupled with ultra-high performance liquid chromatography-tandem mass spectrometry: Analytical methods and occurrence
作者：Ji, Xiaofeng;Xiao, Yingping;Lyu, Wentao;Wang, Wen;Tang, Biao;Yang, Hua;Deng, Tao;Wu, Zhen;Jin, Canghong;Yang, Hua
关键词：Mycotoxins; Alternaria; Food safety; QuEChERS
-
Emerging Alternaria and Fusarium mycotoxins in tomatoes and derived tomato products from the China market: Occurrence, methods of determination, and risk evaluation
作者：Ji, Xiaofeng;Xiao, Yingping;Lyu, Wentao;Wang, Wen;Wang, Xiaoli;Yang, Hua;Deng, Tao;Wu, Zhen;Jin, Canghong;He, Qinfang;Yang, Hua
关键词：Emerging; Alternaria; Fusarium; Mycotoxin; Tomato; Dietary exposure
-
Differences in Bacterial Communities of Retail Raw Pork in Different Market Types in Hangzhou, China
作者：Wang, Wen;Yi, Zhengkai;Ma, Jiele;Yang, Hua;Xiao, Xingning;Cai, Wei;Zhou, Min
关键词：pork; retail markets; high-throughput sequencing; bacterial community; bacterial contamination
-
Rapid detection of multiple resistance genes to last-resort antibiotics in Enterobacteriaceae pathogens by recombinase polymerase amplification combined with lateral flow dipstick
作者：Lu, Chenze;Wang, Jingwen;Huang, Guangrong;Fang, Jiehong;Jiang, Han;Pan, Leiming;Gu, Xiuying;Lu, Wenjing;Chen, Di;Zhang, Cen;Ye, Qin;Xiao, Chaogeng;Liu, Pengpeng;Tang, Yulong;Tang, Biao;Tang, Biao
关键词：recombinase polymerase amplification; lateral flow dipstick; Enterobacteriaceae; rapid detection; resistance genes to last-resort antibiotics
-
Genome-based risk assessment for foodborne Salmonella enterica from food animals in China: A One Health perspective
作者：Tang, Biao;Wu, Jing;Lin, Hui;Tang, Biao;Wu, Jing;Lin, Hui;Siddique, Abubakar;Jia, Chenhao;Ed-Dra, Abdelaziz;Yue, Min;Siddique, Abubakar;Jia, Chenhao;Yue, Min;Yue, Min;Yue, Min
关键词：Salmonella; Food animals; Whole genome sequencing; Antimicrobial resistance gene; One health
