Whole-Grain Highland Barley Attenuates Atherosclerosis Associated with NLRP3 Inflammasome Pathway and Gut Microbiota in ApoE-/- Mice
文献类型： 外文期刊
作者： Wu, Tong 1 ; Yu, Qinye 1 ; Luo, Yingting 1 ; Dai, Zijian 1 ; Zhang, Yuhong 3 ; Wang, Chao 1 ; Shen, Qun 1 ; Xue, Yong 1 ;
作者机构： 1.China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn & Technol Res Ctr Fruits & Vegetables, Beijing 100083, Peoples R China
2.Natl Ctr Technol Innovat Deep Proc Highland Barley, Beijing 100083, Peoples R China
3.Tibet Acad Agr & Anim Husb Sci, Lhasa 850000, Peoples R China
关键词： highland barley; ApoE(-/-) mice; atherosclerosis; NLRP3 inflammasome pathway; gut microbiota
期刊名称：NUTRIENTS （ 影响因子：5.9； 五年影响因子：6.6 ）
ISSN：
年卷期： 2023 年 15 卷 19 期
页码：
收录情况： SCI
摘要： The efficacy and mechanism of highland barley in the treatment of atherosclerosis have received little attention. Herein, we aimed to explore whether highland barley supplementation can prevent atherosclerosis progression and improve gut microbiota disorder in apolipoprotein E knockout (ApoE-/-) mice. Male ApoE-/- mice were fed a high-fat diet with whole-grain highland barley (WHB) or refined highland barley for 18 weeks. WHB substantially inhibited the formation of atherosclerotic plaques, reduced serum tumor necrosis factor-alpha, and downregulated the expression of NLRP3 in the aorta. Furthermore, the 16S rRNA analysis revealed that highland barley supplementation helped to restore the dysregulation of the gut microbiota, as evidenced by an increase in the relative abundance of specific beneficial bacteria known for their anti-inflammatory properties, such as Lachnospiraceae, Lactobacillus, Muribaculaceae, and Bifidobacterium. Highland barley supplementation might alleviate atherosclerotic plaque formation by modulating the NLRP3 inflammasome pathway and the synthesis of anti-inflammatory metabolites by the gut microbiota.
- 相关文献
作者其他论文 更多>>
-
Characteristic volatile compounds, fatty acids and minor bioactive components in oils from green plum seed by HS-GC-IMS, GC-MS and HPLC
作者：Xu, Lirong;Wang, Shihao;Tian, Ailing;Liu, Taorong;Benjakul, Soottawat;Xiao, Gengsheng;Ying, Xiaoguo;Zhang, Yuhong;Ma, Lukai;Ying, Xiaoguo;Ma, Lukai;Zhang, Yuhong
关键词：Green plum seed oil; Flavor compounds; Fatty acids; Bioactive compounds
-
Enhancement of the release of phenolic compounds from white and black Qingke bran by autoclaving and fermentation treatments
作者：He, Caian;Liu, Xiaojiao;Zhang, Haiyan;Mu, Tingting;Ren, Xuechun;Han, Lin;Wang, Min;Zhang, Yuhong
关键词：Qingke bran; Phenolic compounds; Antioxidant capacity; Fermentation
-
Extraction and characterization of waxy and normal barley beta-glucans and their effects on waxy and normal barley starch pasting and degradation properties and mash filtration rate
作者：Li, Qiao;Liu, Juan;Zhai, Huisheng;Zhang, Zhihui;Xie, Rong;Xiao, Futong;Pan, Zhifen;Zeng, Xingquan;Zhang, Yuhong;Li, Zhongyi
关键词：Normal hull-less barley; Waxy hull-less barley; beta-Glucan; Starch pasting; Starch digestion; Mash filtration
-
Intestinal organoid technology and applications in probiotics
作者：Tan, Han;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Xu, Jiahui;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Chen, Xiaoyong;Wang, Chen;Song, Jiajia;Suo, Huayi;Zhang, Yuhong
关键词：Intestinal organoid; probiotic; intestinal health; probiotic mechanisms; intestinal microbiota
-
Silkworm pupa protein and its peptides: Preparation, biological activity, applications in foods, and advantages
作者：Wu, Xiaolin;Zhang, Yu;Wang, Chen;Chen, Xiaoyong;Suo, Huayi;Song, Jiajia;Yang, Jing;Mumby, William;Zhang, Yuhong
关键词：Silkworm pupae; Edible insects; Protein; Bioactive peptides; Biological activity
-
Improved nutritional and antioxidant properties of hulless barley following solid-state fermentation with Saccharomyces cerevisiae and Lactobacillus plantarum
作者：Zhang, Duqin;Tan, Bin;Gao, Kun;Zhang, Yuhong;Ye, Yanjun
关键词：
-
Inhibitory Effect and Potential Mechanism of Lactobacillus plantarum YE4 against Dipeptidyl Peptidase-4
作者：Sha, Jia;Song, Jiajia;Wang, Hongwei;Zhang, Yu;Suo, Huayi;Huang, Yechuan;Zhang, Yuhong
关键词：dipeptidyl peptidase-4; lactic acid bacteria; cell-free extracts; Caco-2 cells
