Genetic diversity and signatures of selection in BoHuai goat revealed by whole-genome sequencing
文献类型: 外文期刊
作者: Yao, Zhi 1 ; Zhang, Shunjin 1 ; Wang, Xianwei 2 ; Guo, Yingwei 1 ; Xin, Xiaoling 3 ; Zhang, Zijing 3 ; Xu, Zejun 2 ; Wang, Eryao 3 ; Jiang, Yu 1 ; Huang, Yongzhen 1 ;
作者机构: 1.Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
2.Henan Prov Anim Husb Gen Stn, Zhengzhou 450008, Henan, Peoples R China
3.Henan Acad Agr Sci, Inst Anim Husb & Vet Sci, Zhengzhou 450002, Henan, Peoples R China
关键词: BoHuai goat; WGS; Genetic diversity; Population structure; Selection
期刊名称:BMC GENOMICS ( 影响因子:4.4; 五年影响因子:4.7 )
ISSN: 1471-2164
年卷期: 2023 年 24 卷 1 期
页码:
收录情况: SCI
摘要: BackgroundCross breeding is an important way to improve livestock performance. As an important livestock and poultry resource in Henan Province of China, Bohuai goat was formed by crossing Boer goat and Huai goat. After more than 20 years of breeding, BoHuai goats showed many advantages, such as fast growth, good reproductive performance, and high meat yield. In order to better develop and protect Bohuai goats, we sequenced the whole genomes of 30 BoHuai goats and 5 Huai goats to analyze the genetic diversity, population structure and genomic regions under selection of BoHuai goat. Furthermore, we used 126 published genomes of world-wide goat to characterize the genomic variation of BoHuai goat.ResultsThe results showed that the nucleotide diversity of BoHuai goats was lower and the degree of linkage imbalance was higher than that of other breeds. The analysis of population structure showed that BoHuai goats have obvious differences from other goat breeds. In addition, the BoHuai goat is more closely related to the Boer goat than the Huai goat and is highly similar to the Boer goat. Group by selection signal in the BoHuai goat study, we found that one region on chromosome 7 shows a very strong selection signal, which suggests that it could well be the segment region under the intense artificial selection results. Through selective sweeps, we detected some genes related to important traits such as lipid metabolism (LDLR, STAR, ANGPTL8), fertility (STAR), and disease resistance (CD274, DHPS, PDCD1LG2).ConclusionIn this paper, we elucidated the genomic variation, ancestry composition, and selective signals related to important economic traits in BoHuai goats. Our studies on the genome of BoHuai goats will not only help to understand the characteristics of the crossbred but also provide a basis for the improvement of cross-breeding programs.
- 相关文献
作者其他论文 更多>>
-
High-density genotyping reveals candidate genomic regions for chicken body size in breeds of Asian origin
作者:Lyu, Shijie;Arends, Danny;Brockmann, Gudrun A.;Lyu, Shijie;Wang, Eryao;Arends, Danny;Nassar, Mostafa K.;Weigend, Annett;Weigend, Steffen
关键词:Asian Game type chicken; Asian Bantam type chicken; growth; GWAS; PCA
-
The relationship between MUC19 copy number variation and growth traits of Chinese cattle
作者:Chen, Yihe;Zhang, Jun;Huang, Yongzhen;Peng, Wei;Fu, Changqi;Zhang, Jun;Zhang, Zijing;Wang, Eryao;Liu, Xian;Wang, Hongli;Zhou, Sensen;Huang, Yongzhen
关键词:Cattle; Copy number variations; MUC19 gene; Association analysis
-
Bta-miR-200b promotes endometrial epithelial cell apoptosis by targeting MYB in cattle
作者:Lyu, Shijie;Zhai, Yaying;Zhu, Xiaoting;Shi, Qiaoting;Chen, Fuying;Zhang, Geyang;Zhang, Zijing;Wang, Eryao;Zhai, Yaying;Zhang, Geyang
关键词:Bovine; miR-200b; Endometrial receptivity; Apoptosis; Proliferation
-
A Chinese indicine pangenome reveals a wealth of novel structural variants introgressed from other Bos species
作者:Dai, Xuelei;Bian, Peipei;Hu, Dexiang;Luo, Funong;Huang, Yongzhen;Jiao, Shaohua;Wang, Xihong;Gong, Mian;Li, Ran;Cai, Yudong;Wen, Jiayue;Yang, Qimeng;Nanaei, Hojjat Asadollahpour;Wang, Yu;Wang, Fei;Jiang, Yu;Deng, Weidong;Nanaei, Hojjat Asadollahpour;Zhang, Zijing;Rosen, Benjamin D.;Heller, Rasmus;Jiang, Yu
关键词:
-
Copy number variation of the ZNF679 gene in cattle and its association analysis with growth traits
作者:Song, Xingya;Li, Xinmiao;Ding, Xiaoting;Lei, Chuzhao;Chen, Hong;Huang, Yongzhen;Li, Xinmiao;Liu, Wujun;Liu, Xian;Li, Zhiming;Ru, Baorui;Zhang, Zijing;Chai, Yanan;Chen, Fuying;Shi, Qiaoting;Wang, Eryao;Wang, Hongli;Li, Jungang;Liang, Huifeng;Sun, Xiaoyan;Yang, Guojie;Qi, Zengfang;Huang, Yongzhen;Liu, Wujun
关键词:ZNF679; Copy number variations (CNVs); Growth traits; Association; Bos taurus (cattle)
-
Identification and Functional Analysis of Transcriptome Profiles, Long Non-Coding RNAs, Single-Nucleotide Polymorphisms, and Alternative Splicing from the Oocyte to the Preimplantation Stage of Sheep by Single-Cell RNA Sequencing
作者:Zhang, Zijing;Shi, Qiaoting;Zhu, Xiaoting;Jin, Lei;Lang, Limin;Lyu, Shijie;Xin, Xiaoling;Xu, Zhaoxue;Wang, Eryao;Huang, Yongzhen;Yu, Xiang;Li, Zhiming;Chen, Sujuan;Zhang, Wei
关键词:transcriptome profiles; long non-coding RNAs; single-nucleotide polymorphisms; alternative splicing; sheep; preimplantation; single-cell RNA sequencing
-
Nitric oxide synthase and its function in animal reproduction: an update
作者:Zhang, Wei;Guo, Li ya;Wang, Xiao meng;Meng, Xiang bo;Zhang, Min ying;Zhang, Ke ke;Li, Yi wei;Wen, Yuliang;Wang, Lei;Hu, Jian he;Zhang, Xiao jian;Chen, Su juan;Zhang, Zijing;Zhang, Jia bin;Chen, Lin lin;Bai, Yue yu
关键词:nitric oxide synthase; structure; location; reproductive functions; regulation mechanism