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Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition

文献类型： 外文期刊

作者： Duan, Zhouwei 1 ; Yu, Shasha 1 ; Wang, Shiping 1 ; Deng, Hao 1 ; Guo, Lijun 3 ; Yang, Hong 2 ; Xie, Hui 1 ;

作者机构： 1.Hainan Acad Agr Sci, Inst Agroprod Proc & Design, Haikou 571100, Hainan, Peoples R China

2.Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China

3.Hainan Acad Agr Sci, Sanya Inst, Sanya 572000, Peoples R China

4.Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China

关键词： piperine; GES-1 cells; gastric mucosal; oxidation

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 22 期

页码：

收录情况： SCI

摘要： Piper nigrum Linnaeus is often used as a treatment for chills, stomach diseases, and other ailments. Piperine has many biological functions; however, its mechanism for preventing gastric mucosal damage is still unclear. The objective of this study was to investigate the preventive effects of piperine on ethanol-induced gastric mucosal injury by using GES-1 cells and rats. SOD, CAT, GSH-Px and MDA were effectively regulated in GES-1 cells pre-treated with piperine. Piperine significantly increased SOD, CAT and GSH-Px activities, but decreased the ulcer area, MDA, ROS and MPO levels in the gastric tissues of rats. RT-PCR analysis showed that piperine downregulated the mRNA expression levels of keap1, JNK, ERK and p38, and upregulated the mRNA transcription levels of Nrf2 and HO-1. Western blotting results indicated that piperine could activate the protein expression levels of Nrf2 and HO-1 and inhibit the protein expression levels of keap1, p-JNK, p-ERK and p-p38. In conclusion, piperine suppressed ethanol-induced gastric ulcers in vitro and in vivo via oxidation inhibition and improving gastric-protecting activity by regulating the Nrf2/HO-1 and MAPK signalling pathways.

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