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Effect of Ivermectin on the Expression of P-Glycoprotein in Third-Stage Larvae of Haemonchus contortus Isolated from China

文献类型： 外文期刊

作者： Luo, Xiaoping 1 ; Wang, Shuyi 4 ; Feng, Ying 1 ; Wang, Penglong 1 ; Gong, Gaowa 1 ; Guo, Tianlong 1 ; Feng, Xingang 3 ; Yang, Xiaoye 2 ; Li, Junyan 1 ;

作者机构： 1.Inner Mongolia Acad Agr & Anim Husb Sci, Key Lab Grass Feeding Livestock Hlth Breeding & Li, Hohhot 010030, Peoples R China

2.Inner Mongolia Agr Univ, Coll Vet Med, Hohhot 010018, Peoples R China

3.Chinese Acad Agr Sci, Shanghai Vet Res Inst, Shanghai 200241, Peoples R China

4.Inner Mongolia Autonomous Reg Comprehens Ctr Dis C, Hohhot 010031, Peoples R China

5.China Agr Univ, Coll Vet Med, Beijing 100193, Peoples R China

关键词： Haemonchus contortus; ivermectin; P-glycoprotein; real-time fluorescence quantitative PCR

期刊名称：ANIMALS （ 影响因子：3.0； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2023 年 13 卷 11 期

页码：

收录情况： SCI

摘要： Haemonchus contortus poses a severe hazard to the healthy development of the sheep industry and threatens the welfare of sheep. Ivermectin is the primary anthelmintic used for the prevention and treatment of H. contortus parasitism. However, the widespread and uncontrolled application of ivermectin has resulted in the development and spread of resistant strains of H. contortus. P-glycoprotein (P-gp) plays important roles in the pharmacology and toxicology of ivermectin, and changes in P-gp expression levels can be used to analyze the resistance of H. contortus to ivermectin. This study aimed to analyze the effects of ivermectin on P-gp expression in H. contortus L3 larvae isolated from China and to evaluate whether changes in P-gp expression levels can be used to analyze resistant H. contortus strains. In the absence of drug treatment, the ivermectin-resistant strains isolated in China showed increased expression of P-gp11 (p < 0.01) compared with sensitive strains from elsewhere, whereas the expressions of P-gp2 and P-gp9.1 were downregulated (p < 0.01). When the same strain was compared before and after drug treatment, obvious differences in expression were observed between the different strains. Ivermectin-induced P-gp expression was found to be very complex among the L3 larvae of different strains. In addition, it was confirmed that using P-gp to determine ivermectin resistance in H. contortus strains from different geographic environments can yield different results.

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