Application of a multiclass screening method for veterinary drugs and pesticides using HPLC-QTOF-MS in egg samples
文献类型： 外文期刊
作者： Hou, Xue 1 ; Xu, Xu 1 ; Xu, Xiaoying 2 ; Han, Mei 1 ; Qiu, Shiting 1 ;
作者机构： 1.Sichuan Acad Agr Sci, Ctr Anal & Testing, Chengdu 610066, Sichuan, Peoples R China
2.Chinese Acad Sci, Chengdu Inst Organ Chem, Chengdu 610041, Sichuan, Peoples R China
3.Minist Agr, Lab Qual & Safety Risk Assessment Agroprod Chengd, Chengdu 610066, Sichuan, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
关键词： Target screening; HPLC-QTOF-MS; HPLC-QqQ-MS; Multiclass residues; Eggs
期刊名称：FOOD CHEMISTRY （ 影响因子：7.514； 五年影响因子：7.516 ）
ISSN： 0308-8146
年卷期： 2020 年 309 卷
页码：
收录情况： SCI
摘要： A multi-class screening method for the determination of veterinary drugs and pesticides in eggs was developed by high performance liquid chromatography quadrupole-time-of-flight mass spectrometry (HPLC-QTOF-MS). A single-injection workflow was developed for qualitative analysis, and method validation was conducted in terms of retention time deviation (Delta Rt), exact mass error (Delta m), selectivity, specificity, precision and trueness. The characteristic fragment ions in information dependent acquisition (IDA) mode were summarized for retrospective and non-target screening. Five of 70 samples were found positive with sulfachloropyridazine, sulfamonomethoxine and fipronil sulfone. Compared with triple-quadrupole (QqQ) MS method, the obtained results showed that QTOF-MS gave comparable results to QqQ-MS with residue concentrations higher than 10 mu g.kg(-1), whereas QqQ-MS was more powerful at lower concentrations (< 1 mu g.kg(-1)). Moreover, the amount of fragment ions acquired by HPLC-QTOF-MS decreased substantially at trace levels, which may be a potential cause of reduced reliability of identification.
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