Comparative transcriptome and histological analyses provide insights into the skin pigmentation in Minxian black fur sheep (Ovis aries)
文献类型： 外文期刊
作者： Shi, Xiaolei 1 ; Wu, Jianping 1 ; Lang, Xia 2 ; Wang, Cailian 2 ; Bai, Yan 1 ; Riley, David Greg 4 ; Liu, Lishan 2 ; Ma, 1 ;
作者机构： 1.Gansu Agr Univ, Coll Anim Sci & Technol, Lanzhou, Gansu, Peoples R China
2.Gansu Acad Agr Sci, Green Agr Inst, Lanzhou, Gansu, Peoples R China
3.Key Lab Sheep Goat & Cattle Germplasm & Straw Fee, Lanzhou, Gansu, Peoples R China
4.Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA
关键词： Sheep; Skin; Pigmentation; RNA sequencing; Histology
期刊名称：PEERJ （ 影响因子：2.379； 五年影响因子：2.81 ）
ISSN： 2167-8359
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： Background. Minxian black fur (MBF) sheep are found in the northwestern parts of China. These sheep have developed several special traits. Skin color is a phenotype subject to strong natural selection and diverse skin colors are likely a consequence of differences in gene regulation. Methods. Skin structure, color differences, and gene expression (determined by RNA sequencing) were evaluated the Minxian black fur and Small-tail Han sheep (n = 3 each group), which are both native Chinese sheep breeds. Results. Small-tail Han sheep have a thicker skin and dermis than the Minxian black fur sheep (P < 0.01); however, the quantity of melanin granules is greater (P < 0.01) in Minxian black fur sheep with a more extensive distribution in skin tissue and hair follicles. One hundred thirty-three differentially expressed genes were significantly associated with 37 ontological terms and two critical KEGG pathways for pigmentation ("tyrosine metabolism'' and "melanogenesis'' pathways). Important genes from those pathways with known involvement in pigmentation included OCA2 melanosomal transmembrane protein (OCA2), dopachrome tautomerase (DCT), tyrosinase (TYR) and tyrosinase related protein (TYRP1), melanocortin 1 receptor (MC1R), and pre-melanosome protein (PMEL). The results from our histological and transcriptome analyses will form a foundation for additional investigation into the genetic basis and regulation of pigmentation in these sheep breeds.
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