文献类型： 外文期刊

作者： Deng, Yanchun ¹ ; Zhao, Hongxia ⁴ ; Shen, Shuo ⁵ ; Yang, Sa ¹ ; Yang, Dahe ¹ ; Deng, Shuai ¹ ; Hou, Chunsheng ¹ ;

作者机构： 1.Chinese Acad Agr Sci, Inst Apicultural Res, Beijing, Peoples R China

2.Minist Agr & Rural Affairs, Key Lab Pollinating Insect Biol, Beijing, Peoples R China

3.Chinese Acad Agr Sci, Grad Sch, Beijing, Peoples R China

4.Guangdong Acad Sci, Guangdong Inst Appl Biol Resources, Guangdong Publ Lab Wild Anim Conservat & Utilizat, Guangdong Key Lab Anim Conservat & Resource Utili, Guangzhou, Peoples R China

5.Qinghai Univ, Acad Agr & Forestry Sci, Qinghai Acad Agr & Forestry Sci, Xining, Peoples R China

关键词： Chinese sacbrood virus; serine protease; Apis cerana; transcriptome; siRNA; immune response

期刊名称：FRONTIERS IN GENETICS （ 影响因子：4.599； 五年影响因子：4.888 ）

ISSN：

年卷期： 2020 年 11 卷

页码：

收录情况： SCI

摘要： Chinese sacbrood virus (CSBV) is a serious threat to eastern honeybees (Apis cerana), especially larvae. However, the pathological mechanism of this deadly disease remains unclear. Here, we employed mRNA and small RNA (sRNA) transcriptome approach to investigate the microRNAs (miRNAs) and small interfering RNAs (siRNAs) expression changes of A. cerana larvae infected with CSBV under natural condition. We found that serine proteases involved in immune response were down-regulated, while the expression of siRNAs targeted to serine proteases were up-regulated. In addition, CSBV infection also affected the expression of larvae cuticle proteins such as larval cuticle proteins A1A and A3A, resulting in increased susceptibility to CSBV infection. Together, our results provide insights into sRNAs that they are likely to be involved in regulating honeybee immune response.